The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer

Metzler, Veronika M.; de Brot, Simone; Haigh, Daisy B.; Woodcock, Corinne L.; Lothion-Roy, Jennifer; Harris, Anna E.; Nilsson, Emeli M.; Ntekim, Atara; Persson, Jenny L.; Robinson, Brian D.; Khani, Francesca; Laursen, Kristian B.; Gudas, Lorraine J.; Toss, Michael S.; Madhusudan, Srinivasan; Rakha, Emad; Heery, David M.; Rutland, Catrin S.; Mongan, Nigel P.; Jeyapalan, Jennie N.

doi:10.3389/fcell.2023.1116424

All Outputs (3)

STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway (2023)
Journal Article
Pencik, J., Philippe, C., Schlederer, M., Atas, E., Pecoraro, M., Grund-Gröschke, S., …Kenner, L. (2023). STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway. Molecular Cancer, 22, Article 133. https://doi.org/10.1186/s12943-023-01825-8

Prostate cancer (PCa) is a common and fatal type of cancer in men. Metastatic PCa (mPCa) is a major factor contributing to its lethality, although the mechanisms remain poorly understood. PTEN is one of the most frequently deleted genes in mPCa. Here... Read More about STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway.

Apoptotic cell death in disease—Current understanding of the NCCD 2023 (2023)
Journal Article
Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J. M., Adam, D., …Galluzzi, L. (2023). Apoptotic cell death in disease—Current understanding of the NCCD 2023. Cell Death and Differentiation, 30(5), 1097-1154. https://doi.org/10.1038/s41418-023-01153-w

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this p... Read More about Apoptotic cell death in disease—Current understanding of the NCCD 2023.

The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer (2023)
Journal Article
Metzler, V. M., de Brot, S., Haigh, D. B., Woodcock, C. L., Lothion-Roy, J., Harris, A. E., …Jeyapalan, J. N. (2023). The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer. Frontiers in Cell and Developmental Biology, 11, Article 1116424. https://doi.org/10.3389/fcell.2023.1116424

Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types... Read More about The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer.