All Outputs (38)

Cardiovascular Fitness and Stride Acceleration in Race-Pace Workouts for the Prediction of Performance in Thoroughbreds (2024)
Journal Article
Schrurs, C., Dubois, G., Van Erck-Westergren, E., & Gardner, D. S. (2024). Cardiovascular Fitness and Stride Acceleration in Race-Pace Workouts for the Prediction of Performance in Thoroughbreds. Animals, 14(9), Article 1342. https://doi.org/10.3390/ani14091342

In-training racehorse physiological data can be leveraged to further explore race-day performance prediction. To date, no large retrospective, observational study has analysed whether in-training speed and heart rate recovery can predict racehorse su... Read More about Cardiovascular Fitness and Stride Acceleration in Race-Pace Workouts for the Prediction of Performance in Thoroughbreds.

Locomotory Profiles in Thoroughbreds: Peak Stride Length and Frequency in Training and Association with Race Outcomes (2022)
Journal Article
Schrurs, C., Blott, S., Dubois, G., Van Erck-Westergren, E., & Gardner, D. S. (2022). Locomotory Profiles in Thoroughbreds: Peak Stride Length and Frequency in Training and Association with Race Outcomes. Animals, 12(23), Article 3269. https://doi.org/10.3390/ani12233269

Racehorses competing in short (i.e., ‘sprinters’), middle- or longer-distance (i.e., ‘stayers’) flat races are assumed to have natural variation in locomotion; sprinters having an innately shorter stride than stayers. No study has objectively tested... Read More about Locomotory Profiles in Thoroughbreds: Peak Stride Length and Frequency in Training and Association with Race Outcomes.

Cryo-scanning electron microscopy demonstrates that ice morphology is not associated with the post-thaw survival of domestic boar (Sus domesticus) spermatozoa: A comparison of directional and conventional freezing methods (2022)
Journal Article
Gillis, J. D., Holt, W. V., Penfold, L. M., Woad, K. J., Graham, J. K., Watts, J. A., …Yon, L. (2022). Cryo-scanning electron microscopy demonstrates that ice morphology is not associated with the post-thaw survival of domestic boar (Sus domesticus) spermatozoa: A comparison of directional and conventional freezing methods. Cryobiology, 108, 10-18. https://doi.org/10.1016/j.cryobiol.2022.08.006

Directional freezing (in 2 or 10 ml hollow glass tubes) has been reported to improve post-thaw sperm survival parameters compared to conventional methods (in 0.5 ml straws). However, the biophysical properties that increase post-thaw survival are poo... Read More about Cryo-scanning electron microscopy demonstrates that ice morphology is not associated with the post-thaw survival of domestic boar (Sus domesticus) spermatozoa: A comparison of directional and conventional freezing methods.

Does sex of the jockey influence racehorse physiology and performance (2022)
Journal Article
Schrurs, C., Dubois, G., Van Erck-Westergren, E., & Gardner, D. S. (2022). Does sex of the jockey influence racehorse physiology and performance. PLoS ONE, 17(8), Article e0273310. https://doi.org/10.1371/journal.pone.0273310

The racing industry is supported by a predominance of female stablehands and work riders, but few become professional jockeys. Female jockeys have recently had notable race success. No study has assessed whether the sex of the rider may subtly influe... Read More about Does sex of the jockey influence racehorse physiology and performance.

Impact of COVID-19 on student attainment and pedagogical needs when undertaking independent scientific research (2022)
Journal Article
Jeyapalan, J. N., James, V., Gardner, D. S., Lothion-Roy, J. H., Mongan, N. P., & Rutland, C. S. (2022). Impact of COVID-19 on student attainment and pedagogical needs when undertaking independent scientific research. Anatomia, Histologia, Embryologia, https://doi.org/10.1111/ahe.12842

Research is often an essential component of completing a veterinary medicine degree, with universities worldwide aiming to teach students a variety of techniques and general research comprehension and skills. As universities worldwide navigated the C... Read More about Impact of COVID-19 on student attainment and pedagogical needs when undertaking independent scientific research.

Development and the Art of Nutritional Maintenance (2022)
Journal Article
Gardner, D. S., & Gray, C. (2022). Development and the Art of Nutritional Maintenance. British Journal of Nutrition, 1-24. https://doi.org/10.1017/S0007114522001490

Development from early conceptus to a complex, multi-cellular organism is a highly ordered process that is dependent on an adequate supply of nutrients. During this process, the pattern of organ growth is robust, driven by a genetic blueprint and mat... Read More about Development and the Art of Nutritional Maintenance.

Urinary Trace Elements Are Biomarkers for Early Detection of Acute Kidney Injury (2022)
Journal Article
Gardner, D. S., Allen, J. C., Goodson, D., Harvey, D., Sharman, A., Skinner, H., …Devonald, M. A. (2022). Urinary Trace Elements Are Biomarkers for Early Detection of Acute Kidney Injury. Kidney International Reports, 7(7), 1524-1538. https://doi.org/10.1016/j.ekir.2022.04.085

Introduction: Acute kidney injury (AKI) is common in hospitalized patients and associated with poor outcomes. Current methods for identifying AKI (rise in serum creatinine [sCr] or fall in urine output [UO]) are inadequate and delay detection. Early... Read More about Urinary Trace Elements Are Biomarkers for Early Detection of Acute Kidney Injury.

Intra-tracheal multiplexed sensing of contact pressure and perfusion (2021)
Journal Article
Correia, R., Gadsby, B., Korposh, S., Norris, A. M., Hayes-Gill, B. R., Sinha, R., …Morgan, S. P. (2022). Intra-tracheal multiplexed sensing of contact pressure and perfusion. Biomedical Optics Express, 13(1), 48-64. https://doi.org/10.1364/BOE.442165

Incorrect endotracheal tube (ETT) cuff inflation pressure causes significant problems for intubated patients. The technical development and first in vivo use of a smart ETT for measurements at the cuff-trachea interface during mechanical ventilation... Read More about Intra-tracheal multiplexed sensing of contact pressure and perfusion.

Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies (2021)
Journal Article
Scaife, P. J., Simpson, A., Kurlak, L. O., Briggs, L. V., Gardner, D. S., Pipkin, F. B., …Mistry, H. D. (2021). Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies. International Journal of Molecular Sciences, 22(14), Article 7295. https://doi.org/10.3390/ijms22147295

Up to 11% of pregnancies extend to post-term with adverse obstetric events linked to pregnancies over 42 weeks. Oxidative stress and senescence (cells stop growing and dividing by irreversibly arresting their cell cycle and gradually ageing) can resu... Read More about Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies.

Maternal protein restriction affects fetal ovary development in sheep (2021)
Journal Article
Nwachukwu, C. U., Woad, K. J., Barnes, N., Gardner, D. S., & Robinson, R. S. (2021). Maternal protein restriction affects fetal ovary development in sheep. Reproduction and Fertility, 2(2), 161-171. https://doi.org/10.1530/raf-20-0073

Maternal malnutrition has important developmental consequences for the foetus. Indeed, adverse fetal ovarian development could have lifelong impact, with potentially reduced ovarian reserve and fertility of the offspring. This study investigated the... Read More about Maternal protein restriction affects fetal ovary development in sheep.

SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells (2020)
Journal Article
Kim, J. Y., Bai, Y., Jayne, L. A., Abdulkader, F., Gandhi, M., Perreau, T., …Pabla, N. S. (2020). SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells. Journal of Biological Chemistry, 295(48), 16328-16341. https://doi.org/10.1074/jbc.RA120.015110

© 2020 Kim et al. Acute kidney injury (AKI) is a common clinical condition associated with diverse etiologies and abrupt loss of renal function. In patients with sepsis, rhabdomyolysis, cancer, and cardiovascular disorders, the underlying disease or... Read More about SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells.

Equine influenza vaccination as reported by horse owners and factors influencing their decision to vaccinate or not (2020)
Journal Article
Bambra, W., Daly, J. M., Kendall, N. R., Gardner, D. S., Brennan, M., & Kydd, J. H. (2020). Equine influenza vaccination as reported by horse owners and factors influencing their decision to vaccinate or not. Preventive Veterinary Medicine, 180, Article 105011. https://doi.org/10.1016/j.prevetmed.2020.105011

Background: Equine influenza virus is a highly contagious respiratory pathogen that causes pyrexia, anorexia, lethargy and coughing in immunologically naïve horses. Vaccines against equine influenza are available and vaccination is 20 mandatory for... Read More about Equine influenza vaccination as reported by horse owners and factors influencing their decision to vaccinate or not.

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury (2020)
Journal Article
Kim, J. Y., Bai, Y., Jayne, L. A., Hector, R. D., Persaud, A. K., Ong, S. S., …Pabla, N. S. (2020). A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury. Nature Communications, 11(1), Article 1924. https://doi.org/10.1038/s41467-020-15638-6

© 2020, The Author(s). Renal tubular epithelial cells (RTECs) perform the essential function of maintaining the constancy of body fluid composition and volume. Toxic, inflammatory, or hypoxic-insults to RTECs can cause systemic fluid imbalance, elect... Read More about A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.

Definition of hourly urine output influences reported incidence and staging of acute kidney injury (2020)
Journal Article
Allen, J. C., Gardner, D. S., Skinner, H., Harvey, D., Sharman, A., & Devonald, M. A. (2020). Definition of hourly urine output influences reported incidence and staging of acute kidney injury. BMC Nephrology, 21(1), Article 19. https://doi.org/10.1186/s12882-019-1678-2

© 2020 The Author(s). Background: Acute kidney injury (AKI) is commonly defined using the KDIGO system, which includes criteria based on reduced urine output (UO). There is no consensus on whether UO should be measured using consecutive hourly readin... Read More about Definition of hourly urine output influences reported incidence and staging of acute kidney injury.

F1000Prime recommendation of Long-term outcomes following kidney transplantation from donors with acute kidney injury. (2019)
Data
Gardner, D. (2019). F1000Prime recommendation of Long-term outcomes following kidney transplantation from donors with acute kidney injury. [Dataset]. https://doi.org/10.3410/f.736024813.793561921

Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score (2018)
Journal Article
Sinha, R., Correia, R., Gardner, D., Grau-Roma, L., de Brot, S., Hardman, J., …Norris, A. (2018). Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score. Laryngoscope Investigative Otolaryngology, 3(4), 257-262. https://doi.org/10.1002/lio2.168

Objectives: Postintubation laryngotracheal injury is common. Assessment of histopathological changes currently requires animal models. We set about developing a viable, resource effective animal model to study these effects and to develop a detailed... Read More about Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score.

Ultrasonographic-based predictive factors influencing successful return to racing after superficial digital flexor tendon injuries in flat racehorses: a retrospective cohort study in 469 Thoroughbred racehorses in Hong Kong (2018)
Journal Article
Alzola, R., Easter, C., Riggs, C., Gardner, D., & Freeman, S. (2018). Ultrasonographic-based predictive factors influencing successful return to racing after superficial digital flexor tendon injuries in flat racehorses: a retrospective cohort study in 469 Thoroughbred racehorses in Hong Kong. Equine Veterinary Journal, 50(5), 602-608. https://doi.org/10.1111/evj.12810

Background: Superficial digital flexor tendon (SDFT) injury is an important health and welfare concern in racehorses. It is generally diagnosed with ultrasonography, predictive ultrasonographic features have not been reported. Objectives: To determi... Read More about Ultrasonographic-based predictive factors influencing successful return to racing after superficial digital flexor tendon injuries in flat racehorses: a retrospective cohort study in 469 Thoroughbred racehorses in Hong Kong.

Ultrasonographic scoring system for superficial digital flexor tendon injuries in horses: intra- and inter-rater variability (2017)
Journal Article
Alzola Domingo, R., Riggs, C. M., Gardner, D. S., & Freeman, S. (2017). Ultrasonographic scoring system for superficial digital flexor tendon injuries in horses: intra- and inter-rater variability. Veterinary Record, 181(24), https://doi.org/10.1136/vr.104233

Superficial digital flexor tendon (SDFT) tendinopathy is an important musculoskeletal problem in horses. The study objective was to validate an ultrasonographic scoring system for SDFT injuries. Ultrasonographic images from 14 Thoroughbred racehorses... Read More about Ultrasonographic scoring system for superficial digital flexor tendon injuries in horses: intra- and inter-rater variability.

Mineral analysis of complete dog and cat foods in the UK and compliance with European guidelines (2017)
Journal Article
Davies, M., Alborough, R., Jones, L., Davis, C., Williams, C., & Gardner, D. S. (2017). Mineral analysis of complete dog and cat foods in the UK and compliance with European guidelines. Scientific Reports, 7(1), 1-9. https://doi.org/10.1038/s41598-017-17159-7

© 2017 The Author(s). Mineral content of complete pet food is regulated to ensure health of the companion animal population. Analysis of adherence to these regulatory guidelines has not been conducted. Here, mineral composition of complete wet (n = 9... Read More about Mineral analysis of complete dog and cat foods in the UK and compliance with European guidelines.

Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis (2017)
Journal Article
Corr, S. A., Gardner, D. S., Langley-Hobbs, S., Ness, M. G., Kitchener, A. C., & Sinclair, K. D. (2017). Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis. Scientific Reports, 7, Article 15685. https://doi.org/10.1038/s41598-017-15902-8

Our recent report detailing the health status of cloned sheep concluded that the animals had aged normally. This is in stark contrast to reports on Dolly (first animal cloned from adult cells) whose diagnoses of osteoarthritis (OA) at 5½ years of age... Read More about Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis.