All Outputs (2)

Small molecules which improve pathogenesis of myotonic dystrophy type 1 (2018)
Journal Article
López-Morató, M., Brook, J. D., & Wojciechowska, M. (2018). Small molecules which improve pathogenesis of myotonic dystrophy type 1. Frontiers in Neurology, 9, Article 349. https://doi.org/10.3389/fneur.2018.00349

Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy in adults for which there is currently no treatment. The pathogenesis of this autosomal dominant disorder is associated with the expansion of CTG repeats in the 3′-UTR of the DMPK... Read More about Small molecules which improve pathogenesis of myotonic dystrophy type 1.

Quantitative methods to monitor RNA biomarkers in myotonic dystrophy (2018)
Journal Article
Wojciechowska, M., Sobczak, K., Kozlowski, P., Sedehizadeh, S., Wojtkowiak-Szlachcic, A., Czubak, K., Markus, R., Lusakowska, A., Kaminska, A., & Brook, J. D. (in press). Quantitative methods to monitor RNA biomarkers in myotonic dystrophy. Scientific Reports, 8, Article 5885. https://doi.org/10.1038/s41598-018-24156-x

Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are human neuromuscular disorders associated with mutations of simple repetitive sequences in afected genes. The abnormal expansion of CTG repeats in the 3′-UTR of the DMPK gene elicits DM1, whereas el... Read More about Quantitative methods to monitor RNA biomarkers in myotonic dystrophy.