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Small molecules which improve pathogenesis of myotonic dystrophy type 1 (2018)
Journal Article
López-Morató, M., Brook, J. D., & Wojciechowska, M. (2018). Small molecules which improve pathogenesis of myotonic dystrophy type 1. Frontiers in Neurology, 9, doi:10.3389/fneur.2018.00349. ISSN 1664-2295

Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy in adults for which there is currently no treatment. The pathogenesis of this autosomal dominant disorder is associated with the expansion of CTG repeats in the 3′-UTR of the DMPK... Read More

Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development (2017)
Journal Article
Ghosh, T. K., Aparicio-Sánchez, J. J., Buxton, S., Ketley, A., Mohamed, T., Rutland, C. S., …Brook, J. D. (2018). Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development. Journal of Molecular and Cellular Cardiology, 114, doi:10.1016/j.yjmcc.2017.11.013. ISSN 0022-2828

TBX5 plays a critical role in heart and forelimb development. Mutations in TBX5 cause Holt-Oram syndrome, an autosomal dominant condition that affects the formation of the heart and upper - limb. Several studies have provided significant insight int... Read More

The miR-30 microRNA family targets smoothened to regulate hedgehog signalling in zebrafish early muscle development (2013)
Journal Article
Ketley, A., Warren, A., Holmes, E., Gering, M., Aboobaker, A. A., & Brook, J. D. (2013). The miR-30 microRNA family targets smoothened to regulate hedgehog signalling in zebrafish early muscle development. PLoS ONE, 8(6), doi:10.1371/journal.pone.0065170. ISSN 1932-6203

The importance of microRNAs in development is now widely accepted. However, identifying the specific targets of individual microRNAs and understanding their biological significance remains a major challenge. We have used the zebrafish model system to... Read More

Formation, contraction, and mechanotransduction of myofribrils in cardiac development: clues from genetics (2012)
Journal Article
Granados-Riveron, J. T., & Brook, D. (2012). Formation, contraction, and mechanotransduction of myofribrils in cardiac development: clues from genetics. Biochemistry Research International, 2012(504906), doi:10.1155/2012/504906. ISSN 2090-2247

Congenital heart disease (CHD) is the most common birth defect in humans. It is a leading infant mortality factor worldwide, caused by defective cardiac development. Mutations in transcription factors, signalling and structural molecules have been sh... Read More