Synthesis and in vitro evaluation of polyethylene glycol-paclitaxel conjugates for lung cancer therapy

Alexander, Cameron; Luo, Tian; Magnusson, Johannes; Bosquillon, Cynthia; Pr�at, V�ronique; Fr�d�rick, Raphael; Vanbever, Rita

doi:10.1007/s11095-016-1908-2

Research Repository

All Outputs (2)

PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma (2016)
Journal Article
Luo, T., Loira-Pastoriza, C., Patil, H. P., Ucakar, B., Muccioli, G. G., Bosquillon, C., & Vanbever, R. (in press). PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma. Journal of Controlled Release, 239, https://doi.org/10.1016/j.jconrel.2016.08.008

Pulmonary delivery offers an attractive route of administration for chemotherapeutic agents, with the advantages of high drug concentrations locally and low side effects systemically. However, fast clearance mechanisms result in short residence time... Read More about PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma.

Synthesis and in vitro evaluation of polyethylene glycol-paclitaxel conjugates for lung cancer therapy (2016)
Journal Article

Purpose
Pulmonary drug delivery is considered an attractive route of drug administration for lung cancer chemotherapy. However, fast clearance mechanisms result in short residence time of small molecule drugs in the lung. Therefore, achieving a sust... Read More about Synthesis and in vitro evaluation of polyethylene glycol-paclitaxel conjugates for lung cancer therapy.