All Outputs (2)

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target (2011)
Journal Article
Sanhaji, M., Friel, C. T., Wordeman, L., Louwen, F., & Yuan, J. (2011). Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target. Oncotarget, 2(12), 935-947. https://doi.org/10.18632/oncotarget.416

The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability. The kinesin-13 family is critical in... Read More about Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.

The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization (2011)
Journal Article
Friel, C. T., & Howard, J. (2011). The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization. EMBO Journal, 30(19), 3928-3939. https://doi.org/10.1038/emboj.2011.290

Unlike other kinesins, members of the kinesin-13 subfamily do not move directionally along microtubules but, instead, depolymerize them. To understand how kinesins with structurally similar motor domains can have such dissimilar functions, we elucida... Read More about The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization.