Variation in lung function and alterations in cardiac 1 structure and function: analysis of the UK Biobank 2 cardiovascular magnetic resonance imaging substudy

Thomson, Ross J.; Aung, Nay; Sanghvi, Mihir M.; Paiva, José Miguel; Lee, Aaron M; Fung, Kenneth; Pfeffer, Paul E.; Mackay, Alexander J.; Mckeever, Tricia M.; Lukaschuk, Elena 5; Carapella, Valentina; Kim, Young Jin; Bolton, Charlotte E.; Piechnik, Stefan K; Neubauer, Stefan; Petersen, Steffen E.

doi:10.1371/journal.pone.0194434

All Outputs (5)

Hip fracture outcomes in patients with COPD (2018)
Journal Article
Buss, L., McKeever, T. M., Nightingale, J., Akyea, R., Ollivere, B., Moppett, I., & Bolton, C. E. (2018). Hip fracture outcomes in patients with COPD. British Journal of Anaesthesia, 121(6), 1377-1379. https://doi.org/10.1016/j.bja.2018.09.008+hideArticle+Info

Hip fractures are common in patients with COPD and contemporary outcome data is needed. Patients admitted with a hip fracture to one acute trust (2010-2015) were assessed prospectively (UK National Hip Fracture Database audit) and mortality data col... Read More about Hip fracture outcomes in patients with COPD.

TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations (2018)
Journal Article
Mallia-Milanes, B., Dufour, A., Philp, C., Solis, N., Klein, T., Fischer, M., …Johnson, S. R. (2018). TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations. AJP - Lung Cellular and Molecular Physiology, 315(6), L1003-L1014. https://doi.org/10.1152/ajplung.00175.2018

© 2018 the American Physiological Society. Dys-regulated protease activity is thought to cause parenchymal and airway damage in chronic obstructive pulmonary disease (COPD). Multiple proteases have been implicated in COPD, and identifying their subst... Read More about TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations.

Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study (2018)
Journal Article
Mohan, D., Forman, J. R., Allinder, M., McEniery, C. M., Bolton, C. E., Cockcroft, J. R., MacNee, W., Fuld, J., Marchong, M., Gale, N. S., Fisk, M., Nagarajan, S., Cheriyan, J., Lomas, D. A., Calverley, P. M., Miller, B. E., Tal-Singer, R., Wilkinson, I. B., & Polkey, M. I. (2018). Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study. Thorax, 73(12), 1182-1185. https://doi.org/10.1136/thoraxjnl-2018-211556

Cardiovascular and skeletal muscle manifestations constitute important comorbidities in COPD, with systemic inflammation proposed as a common mechanistic link. Fibrinogen has prognostic role in COPD. We aimed to determine whether aortic stiffness and... Read More about Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study.

Risk of fall in patients with COPD (2018)
Journal Article
Hakamy, A., Bolton, C. E., Gibson, J. E., & McKeever, T. M. (2018). Risk of fall in patients with COPD. Thorax, 73(11), 1079-1080. https://doi.org/10.1136/thoraxjnl-2017-211008

A matched cohort study was conducted to determine the incidence of falls in patients following a diagnosis of COPD using a UK primary care database. 44 400 patients with COPD and 175 545 non-COPD subjects were identified. The incidence rate of fall p... Read More about Risk of fall in patients with COPD.

Variation in lung function and alterations in cardiac 1 structure and function: analysis of the UK Biobank 2 cardiovascular magnetic resonance imaging substudy (2018)
Journal Article
Thomson, R. J., Aung, N., Sanghvi, M. M., Paiva, J. M., Lee, A. M., Fung, K., …Petersen, S. E. (2018). Variation in lung function and alterations in cardiac 1 structure and function: analysis of the UK Biobank 2 cardiovascular magnetic resonance imaging substudy. PLoS ONE, 13(3), Article e0194434. https://doi.org/10.1371/journal.pone.0194434

Background

Reduced lung function is common and associated with increased cardiovascular morbidity and mortality, even in asymptomatic individuals without diagnosed respiratory disease. Previous studies have identified relationships between lung fu... Read More about Variation in lung function and alterations in cardiac 1 structure and function: analysis of the UK Biobank 2 cardiovascular magnetic resonance imaging substudy.