All Outputs (2)

In Vitro Anticancer Properties of Novel Bis-Triazoles (2022)
Journal Article
Saleh, M. M., Abuarqoub, D. A., Hammad, A. M., Hossan, M. S., Ahmed, N., Aslam, N., …Bradshaw, T. D. (2023). In Vitro Anticancer Properties of Novel Bis-Triazoles. Current Issues in Molecular Biology, 45(1), 175-196. https://doi.org/10.3390/cimb45010014

Here, we describe the anticancer activity of our novel bis-triazoles MS47 and MS49, developed previously as G-quadruplex stabilizers, focusing specifically upon the human melanoma MDA-MB-435 cell line. At the National Cancer Institute (NCI), USA, bis... Read More about In Vitro Anticancer Properties of Novel Bis-Triazoles.

Development of fluorescent peptide G protein-coupled receptor activation biosensors for NanoBRET characterization of intracellular allosteric modulators (2022)
Journal Article
Farmer, J. P., Mistry, S. N., Laughton, C. A., & Holliday, N. D. (2022). Development of fluorescent peptide G protein-coupled receptor activation biosensors for NanoBRET characterization of intracellular allosteric modulators. FASEB Journal, 36(11), Article e22576. https://doi.org/10.1096/fj.202201024R

G protein-coupled receptors (GPCRs) are widely therapeutically targeted, and recent advances in allosteric modulator development at these receptors offer further potential for exploitation. Intracellular allosteric modulators (IAM) represent a class... Read More about Development of fluorescent peptide G protein-coupled receptor activation biosensors for NanoBRET characterization of intracellular allosteric modulators.