All Outputs (2)

Comparative analysis of protein expression systems and PTM landscape in the study of transcription factor ELK-1 (2022)
Journal Article
Ducker, C., Ratnam, M., Shaw, P. E., & Layfield, R. (2023). Comparative analysis of protein expression systems and PTM landscape in the study of transcription factor ELK-1. Protein Expression and Purification, 203, Article 106216. https://doi.org/10.1016/j.pep.2022.106216

Post-translational modifications (PTMs) are important for protein folding and activity, and the ability to recreate physiologically relevant PTM profiles on recombinantly-expressed proteins is vital for meaningful functional analysis. The ETS transcr... Read More about Comparative analysis of protein expression systems and PTM landscape in the study of transcription factor ELK-1.

Identification of ELK1 interacting peptide segments in the androgen receptor (2022)
Journal Article
Ducker, C., Kim, S., Strahl, T., Rosati, R., Huang, Y., Shaw, P. E., & Ratnam, M. (2022). Identification of ELK1 interacting peptide segments in the androgen receptor. Biochemical Journal, 479(14), 1519-1531. https://doi.org/10.1042/bcj20220297

Prostate cancer (PCa) growth requires tethering of the androgen receptor (AR) to chromatin by the ETS domain transcription factor ELK1 to coactivate critical cell proliferation genes. Disruption of the ELK1–AR complex is a validated potential means o... Read More about Identification of ELK1 interacting peptide segments in the androgen receptor.