All Outputs (7)

Multiple novel caliciviruses identified from stoats (Mustela erminea) in the United Kingdom (2024)
Journal Article
Hinds, J., Apaa, T., Parry, R. H., Withers, A. J., MacKenzie, L., Staley, C., Morrison, J., Bennett, M., Bremner-Harrison, S., Chadwick, E. A., Hailer, F., Harrison, S. W., Lambin, X., Loose, M., Mathews, F., Tarlinton, R., & Blanchard, A. (2024). Multiple novel caliciviruses identified from stoats (Mustela erminea) in the United Kingdom. Access Microbiology, 6(7), Article 000813.v4. https://doi.org/10.1099/acmi.0.000813.v4

The Caliciviridae family, comprising positive-sense RNA viruses, is characterised by its non-enveloped, small virions, broad host range, and notable tendency for host switching. These viruses are primarily associated with gastroenteric disease, thoug... Read More about Multiple novel caliciviruses identified from stoats (Mustela erminea) in the United Kingdom.

Integrating cryo-OrbiSIMS with computational modelling and metadynamics simulations enhances RNA structure prediction at atomic resolution (2024)
Journal Article
Ward, S., Childs, A., Staley, C., Waugh, C., Watts, J. A., Kotowska, A. M., …Borkar, A. N. (2024). Integrating cryo-OrbiSIMS with computational modelling and metadynamics simulations enhances RNA structure prediction at atomic resolution. Nature Communications, 15(1), Article 4367. https://doi.org/10.1038/s41467-024-48694-3

The 3D architecture of RNAs governs their molecular interactions, chemical reactions, and biological functions. However, a large number of RNAs and their protein complexes remain poorly understood due to the limitations of conventional structural bio... Read More about Integrating cryo-OrbiSIMS with computational modelling and metadynamics simulations enhances RNA structure prediction at atomic resolution.

Natural Mycoplasma Infection Reduces Expression of Pro-Inflammatory Cytokines in Response to Ovine Footrot Pathogens (2022)
Journal Article
Blanchard, A. M., Baumbach, C. M., Michler, J. K., Pickwell, N. D., Staley, C. E., Franklin, J. M., Wattegedera, S. R., Entrican, G., & Tötemeyer, S. (2022). Natural Mycoplasma Infection Reduces Expression of Pro-Inflammatory Cytokines in Response to Ovine Footrot Pathogens. Animals, 12(23), Article 3235. https://doi.org/10.3390/ani12233235

Ovine footrot is a complex multifactorial infectious disease, causing lameness in sheep with major welfare and economic consequences. Dichelobacter nodosus is the main causative bacterium; however, footrot is a polymicrobial disease with Fusobacteriu... Read More about Natural Mycoplasma Infection Reduces Expression of Pro-Inflammatory Cytokines in Response to Ovine Footrot Pathogens.

Failure to detect Schmallenberg Virus in ram semen in the UK (2016-2018) (2022)
Journal Article
Curwen, A., Jones, S., Stayley, C., Eden, L., McKay, H., Davies, P., …Tarlinton, R. (2022). Failure to detect Schmallenberg Virus in ram semen in the UK (2016-2018). Veterinary Record Open, 9(1), Article e39. https://doi.org/10.1002/vro2.39

Background
Schmallenberg virus is a midge borne arbovirus that first emerged in the European ruminant population in 2011 and has since settled to an endemic pattern of disease The impacts of trade restrictions on genetic products (semen, embryos) f... Read More about Failure to detect Schmallenberg Virus in ram semen in the UK (2016-2018).

A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions (2021)
Journal Article
Blanchard, A. M., Staley, C. E., Shaw, L., Wattegedera, S. R., Baumbach, C.-M., Michler, J. K., …Tötemeyer, S. (2021). A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions. Infection and Immunity, 89(10), Article e00270-21. https://doi.org/10.1128/iai.00270-21

Footrot is a polymicrobial infectious disease in sheep causing severe lameness, leading to one of the industry’s largest welfare problems. The complex etiology of footrot makes in situ or in vitro investigations difficult. Computational methods offer... Read More about A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions.

Genomic heterogeneity of Dichelobacter nodosus within and between UK sheep flocks and between age groups within a flock (2020)
Journal Article
Davies, P. L., Blanchard, A. M., Staley, C. E., Bollard, N. J., Coffey, T. J., & Tötemeyer, S. (2020). Genomic heterogeneity of Dichelobacter nodosus within and between UK sheep flocks and between age groups within a flock. BMC Microbiology, 20, Article 107. https://doi.org/10.1186/s12866-020-01769-9

Background
Footrot and interdigital dermatitis are endemic infectious diseases in all sheep farming regions, impairing welfare and production. The development of efficacious vaccines against the primary causative pathogen has been hampered by the ex... Read More about Genomic heterogeneity of Dichelobacter nodosus within and between UK sheep flocks and between age groups within a flock.

The applied development of a tiered multilocus sequence typing (MLST) scheme for Dichelobacter nodosus (2018)
Journal Article
Blanchard, A. M., Jolley, K. A., Maiden, M. C., Coffey, T. J., Maboni, G., Staley, C. E., Bollard, N., Warry, A., Emes, R. D., Davies, P., & Tötemeyer, S. (in press). The applied development of a tiered multilocus sequence typing (MLST) scheme for Dichelobacter nodosus. Frontiers in Microbiology, 9, Article 551. https://doi.org/10.3389/fmicb.2018.00551

Dichelobacter nodosus (D. nodosus) is the causative pathogen of ovine footrot, a disease that has a significant welfare and financial impact on the global sheep industry. Previous studies into the phylogenetics of D. nodosus have focused on Australia... Read More about The applied development of a tiered multilocus sequence typing (MLST) scheme for Dichelobacter nodosus.