Skip to main content

Research Repository

Advanced Search

All Outputs (95)

Hormone replacement therapy and cancer mortality in women with 17 site-specific cancers: a cohort study using linked medical records (2024)
Journal Article
Cardwell, C. R., Ranger, T. A., Labeit, A. M., Coupland, C. A. C., Hicks, B., Hughes, C., …Hippisley-Cox, J. (in press). Hormone replacement therapy and cancer mortality in women with 17 site-specific cancers: a cohort study using linked medical records. British Journal of Cancer, https://doi.org/10.1038/s41416-024-02767-8

Background: There is limited evidence on the safety of Hormone Replacement Therapy (HRT) in women with cancer. Therefore, we systematically examined HRT use and cancer-specific mortality in women with 17 site-specific cancers. Methods: Women newly di... Read More about Hormone replacement therapy and cancer mortality in women with 17 site-specific cancers: a cohort study using linked medical records.

Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England (2024)
Journal Article
Chen, D. T.-H., Copland, E., Hirst, J. A., Mi, E., Dixon, S., Coupland, C., & Hippisley-Cox, J. (2024). Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England. BMC Medicine, 22(1), Article 237. https://doi.org/10.1186/s12916-024-03457-1

Background: Immunocompromised individuals are at increased risk of severe COVID-19 outcomes, underscoring the importance of COVID-19 vaccination in this population. The lack of comprehensive real world data on vaccine uptake, effectiveness and safety... Read More about Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England.

Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England (2024)
Journal Article
Copland, E., Patone, M., Saatci, D., Handunnetthi, L., Hirst, J., Hunt, D. P. J., …Hippisley-Cox, J. (2024). Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England. Nature Communications, 15(1), Article 3822. https://doi.org/10.1038/s41467-024-47745-z

The risk-benefit profile of COVID-19 vaccination in children remains uncertain. A self-controlled case-series study was conducted using linked data of 5.1 million children in England to compare risks of hospitalisation from vaccine safety outcomes af... Read More about Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England.

Fatigue during the COVID-19 pandemic – prevalence and predictors: findings from a prospective cohort study (2024)
Journal Article
Kalfas, M., Ayling, K., Jia, R., Coupland, C., Vedhara, K., & Chalder, T. (2024). Fatigue during the COVID-19 pandemic – prevalence and predictors: findings from a prospective cohort study. Stress, 27(1), Article 2352117. https://doi.org/10.1080/10253890.2024.2352117

The COVID-19 pandemic and consequent lockdowns had a substantial impact on mental health. Distress and fatigue are highly correlated. However, little is known about the determinants of fatigue in the general population during the pandemic. This study... Read More about Fatigue during the COVID-19 pandemic – prevalence and predictors: findings from a prospective cohort study.

Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal–external validation of a clinical risk prediction model (2024)
Journal Article
Clift, A. K., Tan, P. S., Patone, M., Liao, W., Coupland, C., Bashford-Rogers, R., …Hippisley-Cox, J. (2024). Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal–external validation of a clinical risk prediction model. British Journal of Cancer, https://doi.org/10.1038/s41416-024-02693-9

Background: The National Institute for Health and Care Excellence (NICE) recommends that people aged 60+ years with newly diagnosed diabetes and weight loss undergo abdominal imaging to assess for pancreatic cancer. More nuanced stratification could... Read More about Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal–external validation of a clinical risk prediction model.

Development and validation of a new algorithm for improved cardiovascular risk prediction (2024)
Journal Article
Hippisley-Cox, J., Coupland, C. A. C., Bafadhel, M., Russell, R. E. K., Sheikh, A., Brindle, P., & Channon, K. M. (2024). Development and validation of a new algorithm for improved cardiovascular risk prediction. Nature Medicine, 30, 1440-1447. https://doi.org/10.1038/s41591-024-02905-y

QRISK algorithms use data from millions of people to help clinicians identify individuals at high risk of cardiovascular disease (CVD). Here, we derive and externally validate a new algorithm, which we have named QR4, that incorporates novel risk fac... Read More about Development and validation of a new algorithm for improved cardiovascular risk prediction.

Effectiveness and safety of COVID-19 vaccination in people with blood cancer (2024)
Journal Article
Copland, E., Hirst, J., Mi, E., Patone, M., Chen, D., Coupland, C., & Hippisley-Cox, J. (2024). Effectiveness and safety of COVID-19 vaccination in people with blood cancer. European Journal of Cancer, 201, Article 113603. https://doi.org/10.1016/j.ejca.2024.113603

Background People with blood cancer have increased risk of severe COVID-19 outcomes and poor response to vaccination. We assessed the safety and effectiveness of COVID-19 vaccines in this vulnerable group compared to the general population. Methods... Read More about Effectiveness and safety of COVID-19 vaccination in people with blood cancer.

Dynamic updating of clinical survival prediction models in a changing environment (2023)
Journal Article
Tanner, K. T., Keogh, R. H., Coupland, C. A. C., Hippisley-Cox, J., & Diaz-Ordaz, K. (2023). Dynamic updating of clinical survival prediction models in a changing environment. Diagnostic and Prognostic Research, 7, Article 24. https://doi.org/10.1186/s41512-023-00163-z

Background Over time, the performance of clinical prediction models may deteriorate due to changes in clinical management, data quality, disease risk and/or patient mix. Such prediction models must be updated in order to remain useful. In this study... Read More about Dynamic updating of clinical survival prediction models in a changing environment.

Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study (2023)
Journal Article
Thompson, W., Swain, S., Zhao, S. S., Kamps, A., Coupland, C., Kuo, C., …Zhang, W. (2023). Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study. Osteoarthritis and Cartilage Open, 5(4), Article 100414. https://doi.org/10.1016/j.ocarto.2023.100414

Objective To investigate the causal association between Osteoarthritis (OA) and five comorbidities: depression, tiredness, multisite chronic pain, irritable bowel syndrome (IBS) and gout.... Read More about Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study.

Development and validation of a novel risk prediction algorithm to estimate 10-year risk of oesophageal cancer in primary care: prospective cohort study and evaluation of performance against two other risk prediction models (2023)
Journal Article
Hippisley-Cox, J., Mei, W., Fitzgerald, R., & Coupland, C. (2023). Development and validation of a novel risk prediction algorithm to estimate 10-year risk of oesophageal cancer in primary care: prospective cohort study and evaluation of performance against two other risk prediction models. The Lancet Regional Health Europe, 32, Article 100700. https://doi.org/10.1016/j.lanepe.2023.100700

Background: Methods to identify patients at increased risk of oesophageal cancer are needed to better identify those for targeted screening. We aimed to derive and validate novel risk prediction algorithms (CanPredict) to estimate the 10-year risk of... Read More about Development and validation of a novel risk prediction algorithm to estimate 10-year risk of oesophageal cancer in primary care: prospective cohort study and evaluation of performance against two other risk prediction models.

Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study (2023)
Journal Article
Hippisley-Cox, J., Khunti, K., Sheikh, A., Nguyen-Van-Tam, J. S., & Coupland, C. A. (2023). Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study. British Medical Journal, 381, Article e072976. https://doi.org/10.1136/bmj-2022-072976

Objectives To derive and validate risk prediction algorithms (QCOVID4) to estimate the risk of covid-19 related death and hospital admission in people with a positive SARS-CoV-2 test result during the period when the omicron variant of the virus was... Read More about Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study.

Disparities in care and outcomes for primary liver cancer in England during 2008–2018: a cohort study of 8.52 million primary care population using the QResearch database (2023)
Journal Article
Liao, W., Coupland, C. A., Innes, H., Jepsen, P., Matthews, P. C., Campbell, C., …Welberry, C. (2023). Disparities in care and outcomes for primary liver cancer in England during 2008–2018: a cohort study of 8.52 million primary care population using the QResearch database. eClinicalMedicine, 59, Article 101969. https://doi.org/10.1016/j.eclinm.2023.101969

Background: Liver cancer has one of the fastest rising incidence and mortality rates among all cancers in the UK, but it receives little attention. This study aims to understand the disparities in epidemiology and clinical pathways of primary liver c... Read More about Disparities in care and outcomes for primary liver cancer in England during 2008–2018: a cohort study of 8.52 million primary care population using the QResearch database.

Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models (2023)
Journal Article
Liao, W., Coupland, C., Burchardt, J., Baldwin, D. R., Gleeson, F. V., Hippisley-Cox, J., & DART initiative. (2023). Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models. Lancet Respiratory Medicine, https://doi.org/10.1016/S2213-2600%2823%2900050-4

Background: Lung cancer is the second most common cancer in incidence and the leading cause of cancer deaths worldwide. Meanwhile, lung cancer screening with low-dose CT can reduce mortality. The UK National Screening Committee recommended targeted l... Read More about Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models.

Ethnic disparities in COVID-19 outcomes: a multinational cohort study of 20 million individuals from England and Canada (2023)
Journal Article
Zaccardi, F., Tan, P. S., Shah, B. R., Everett, K., Clift, A. K., Patone, M., …Hippisley-Cox, J. (2023). Ethnic disparities in COVID-19 outcomes: a multinational cohort study of 20 million individuals from England and Canada. BMC Public Health, 23(1), Article 399. https://doi.org/10.1186/s12889-023-15223-8

Background: Heterogeneous studies have demonstrated ethnic inequalities in the risk of SARS-CoV-2 infection and adverse COVID-19 outcomes. This study evaluates the association between ethnicity and COVID-19 outcomes in two large population-based coho... Read More about Ethnic disparities in COVID-19 outcomes: a multinational cohort study of 20 million individuals from England and Canada.

Uptake of COVID-19 vaccination in people with blood cancer: Population-level cohort study of 12 million patients in England (2023)
Journal Article
Hirst, J., Mi, E., Copland, E., Patone, M., Coupland, C., & Hippisley-Cox, J. (2023). Uptake of COVID-19 vaccination in people with blood cancer: Population-level cohort study of 12 million patients in England. European Journal of Cancer, 183, 162-170. https://doi.org/10.1016/j.ejca.2023.02.001

Background: People with blood cancers have increased risk of severe outcomes from COVID-19 and were prioritised for vaccination. Methods: Individuals in the QResearch database aged 12 years and above on 1st December 2020 were included in the analysis... Read More about Uptake of COVID-19 vaccination in people with blood cancer: Population-level cohort study of 12 million patients in England.

Cost-effectiveness of England's national 'Safe At Home' scheme for reducing hospital admissions for unintentional injury in children aged under 5 (2022)
Journal Article
Jones, M., Hill, T., Coupland, C., Kendrick, D., Akbari, A., Rodgers, S., …Orton, E. (2022). Cost-effectiveness of England's national 'Safe At Home' scheme for reducing hospital admissions for unintentional injury in children aged under 5. Injury Prevention, https://doi.org/10.1136/ip-2022-044698

Background: Injuries in children aged under 5 years most commonly occur in the home and disproportionately affect those living in the most disadvantaged communities. The 'Safe at Home' (SAH) national home safety equipment scheme, which ran in England... Read More about Cost-effectiveness of England's national 'Safe At Home' scheme for reducing hospital admissions for unintentional injury in children aged under 5.

Preexisting Neuropsychiatric Conditions and Associated Risk of Severe COVID-19 Infection and Other Acute Respiratory Infections (2022)
Journal Article
Ranger, T. A., Clift, A. K., Patone, M., Coupland, C. A. C., Hatch, R., Thomas, K., …Hippisley-Cox, J. (2022). Preexisting Neuropsychiatric Conditions and Associated Risk of Severe COVID-19 Infection and Other Acute Respiratory Infections. JAMA Psychiatry, 80(1), 57-65. https://doi.org/10.1001/jamapsychiatry.2022.3614

Importance Evidence indicates that preexisting neuropsychiatric conditions confer increased risks of severe outcomes from COVID-19 infection. It is unclear how this increased risk compares with risks associated with other severe acute respiratory inf... Read More about Preexisting Neuropsychiatric Conditions and Associated Risk of Severe COVID-19 Infection and Other Acute Respiratory Infections.

Design decisions and data completeness for experience sampling methods used in psychosis: systematic review (2022)
Journal Article
Deakin, E., Ng, F., Young, E., Thorpe, N., Newby, C., Coupland, C., …Slade, M. (2022). Design decisions and data completeness for experience sampling methods used in psychosis: systematic review. BMC Psychiatry, 22, Article 669. https://doi.org/10.1186/s12888-022-04319-x

Background: The experience sampling method (ESM) is an intensive longitudinal research method. Participants complete questionnaires at multiple times about their current or very recent state. The design of ESM studies is complex. People with psychosi... Read More about Design decisions and data completeness for experience sampling methods used in psychosis: systematic review.

Associations of BMI with COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes after vaccination in England: a population-based cohort study (2022)
Journal Article
Piernas, C., Patone, M., Astbury, N. M., Gao, M., Sheikh, A., Khunti, K., …Jebb, S. A. (2022). Associations of BMI with COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes after vaccination in England: a population-based cohort study. Lancet Diabetes and Endocrinology, 10(8), 571-580. https://doi.org/10.1016/s2213-8587%2822%2900158-9

Background: A high BMI has been associated with a reduced immune response to vaccination against influenza. We aimed to investigate the association between BMI and COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes a... Read More about Associations of BMI with COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes after vaccination in England: a population-based cohort study.