OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems

Mendonca, Tania; Lis-Slimak, Katarzyna; Matheson, Andrew B.; Smith, Matthew G.; Anane-Adjei, Akosua B.; Ashworth, Jennifer C.; Cavanagh, Robert; Paterson, Lynn; Dalgarno, Paul A.; Alexander, Cameron; Tassieri, Manlio; Merry, Catherine L. R.; Wright, Amanda J.

doi:10.1038/s42003-023-04780-8

All Outputs (3)

Chain-extension in hyperbranched polymers alters tissue distribution and cytotoxicity profiles in orthotopic models of triple negative breast cancers (2023)
Journal Article
Moloney, C., Mehradnia, F., Cavanagh, R. J., Ibrahim, A., Pearce, A. K., Ritchie, A. A., …Alexander, C. (2023). Chain-extension in hyperbranched polymers alters tissue distribution and cytotoxicity profiles in orthotopic models of triple negative breast cancers. Biomaterials Science, 11, 6545-6560. https://doi.org/10.1039/d3bm00609c

The therapeutic efficacy of nanomedicines is highly dependent on their access to target sites in the body, and this in turn is markedly affected by their size, shape and transport properties in tissue. Although there have been many studies in this ar... Read More about Chain-extension in hyperbranched polymers alters tissue distribution and cytotoxicity profiles in orthotopic models of triple negative breast cancers.

Connecting inflammatory bowel and neurodegenerative diseases: microRNAs as a shared therapeutic intervention (2023)
Journal Article
Monaghan, T. M., Ugun-Klusek, A., Finelli, M., Gurnani, P., Chakrabarti, L., Kao, D., …Polytarchou, C. (2024). Connecting inflammatory bowel and neurodegenerative diseases: microRNAs as a shared therapeutic intervention. Gut, 73(6), 1034-1036. https://doi.org/10.1136/gutjnl-2022-327301

OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems (2023)
Journal Article
Mendonca, T., Lis-Slimak, K., Matheson, A. B., Smith, M. G., Anane-Adjei, A. B., Ashworth, J. C., …Wright, A. J. (2023). OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems. Communications Biology, 6, Article 463. https://doi.org/10.1038/s42003-023-04780-8

Biomechanical cues from the extracellular matrix (ECM) are essential for directing many cellular processes, from normal development and repair, to disease progression. To better understand cell-matrix interactions, we have developed a new instrument... Read More about OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems.