Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells

Jean-Gilles, L.; Braitch, M.; Latif, M. L.; Aram, J.; Fahey, A. J.; Edwards, L. J.; Robins, R. A.; Tanasescu, R.; Tighe, P. J.; Gran, B.; Showe, L. C.; Alexander, S. P.; Chapman, V.; Kendall, D. A.; Constantinescu, C. S.

doi:10.1111/apha.12474

Sjogren's myelitis presenting as hemicord syndrome (2023)
Journal Article
Lee, A., Pande, I., & Gran, B. (2023). Sjogren's myelitis presenting as hemicord syndrome. Clinical Medicine, 23(4), 423-424. https://doi.org/10.7861/clinmed.2023-0158

We present a case where a 63-year-old right-handed man who presented with a 6-month history of progressive asymmetrical sensorimotor symptoms in lower limbs. This was associated with concomitant rash on the lower limbs, and mild sicca symptoms. MRI s... Read More about Sjogren's myelitis presenting as hemicord syndrome.

ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK. (2023)
Journal Article
Jacobs, B. M., Schalk, L., Dunne, A., Scalfari, A., Nandoskar, A., Gran, B., …Dobson, R. (2023). ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK. BMJ Open, 13(5), Article e071656. https://doi.org/10.1136/bmjopen-2023-071656

Purpose Genetic studies of multiple sclerosis (MS) susceptibility and severity have focused on populations of European ancestry. Studying MS genetics in other ancestral groups is necessary to determine the generalisability of these findings. The gene... Read More about ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK..

Investigating the Effect of Cigarette Smoking on Serum Uric Acid Levels in Multiple Sclerosis Patients: A Cross Sectional Study (2023)
Journal Article
Alrouji, M., Manouchehrinia, A., Aram, J., Alotaibi, A., Alhajlah, S., Almuhanna, Y., …Constantinescu, C. S. (2023). Investigating the Effect of Cigarette Smoking on Serum Uric Acid Levels in Multiple Sclerosis Patients: A Cross Sectional Study. Brain Sciences, 13(5), Article 800. https://doi.org/10.3390/brainsci13050800

Objectives: The present study is aimed at determining the effect of cigarette smoking (CS) on serum uric acid (UA) levels quantitatively before and after smoking cessation among people with MS (pwMS). Additionally, a possible correlation between UA l... Read More about Investigating the Effect of Cigarette Smoking on Serum Uric Acid Levels in Multiple Sclerosis Patients: A Cross Sectional Study.

SVOA Neurology Sera from Patients with Multiple Sclerosis in Relapse or Remission Affect the Blood-Brain Barrier Differently: An In vitro Study (2022)
Journal Article
Mathur, M., Gran, B., Tanasescu, R., Constantinescu, C. S., Bayraktutan, U., & Bayraktutan, U. (2022). SVOA Neurology Sera from Patients with Multiple Sclerosis in Relapse or Remission Affect the Blood-Brain Barrier Differently: An In vitro Study. SVOA Neurology, 3(5), 208-213

Background: Breakdown of the blood-brain barrier (BBB) constitutes a key step in the pathogenesis of multiple sclerosis (MS). Aims: To investigate whether sera from MS patients in relapse or in remission may differently affect the BBB function and... Read More about SVOA Neurology Sera from Patients with Multiple Sclerosis in Relapse or Remission Affect the Blood-Brain Barrier Differently: An In vitro Study.

Multiple sclerosis and the risk of infection: Association of British Neurologists consensus guideline (2022)
Journal Article
Cauchi, M., Willis, M., Andrews, A., Backx, M., Brownlee, W., Ford, H. L., …Tallantyre, E. C. (2022). Multiple sclerosis and the risk of infection: Association of British Neurologists consensus guideline. Practical Neurology, 22(5), 344-357. https://doi.org/10.1136/practneurol-2022-003370

Infection in people with multiple sclerosis (MS) is of major concern, particularly for those receiving disease-modifying therapies. This article explores the risk of infection in people with MS and provides guidance - developed by Delphi consensus by... Read More about Multiple sclerosis and the risk of infection: Association of British Neurologists consensus guideline.

Editorial: Preventing multiple sclerosis (2022)
Journal Article
Dobson, R., Tanasescu, R., & Gran, B. (2022). Editorial: Preventing multiple sclerosis. Frontiers in Neurology, 13, Article 982411. https://doi.org/10.3389/fneur.2022.982411

The Potential for EBV Vaccines to Prevent Multiple Sclerosis (2022)
Journal Article
Maple, P. A., Ascherio, A., Cohen, J. I., Cutter, G., Giovannoni, G., Shannon-Lowe, C., …Gran, B. (2022). The Potential for EBV Vaccines to Prevent Multiple Sclerosis. Frontiers in Neurology, 13, https://doi.org/10.3389/fneur.2022.887794

There is increasing evidence suggesting that Epstein-Barr virus infection is a causative factor of multiple sclerosis (MS). Epstein-Barr virus (EBV) is a human herpesvirus, Human Gammaherpesvirus 4. EBV infection shows two peaks: firstly, during earl... Read More about The Potential for EBV Vaccines to Prevent Multiple Sclerosis.

Clinical Utility of Cerebrospinal Fluid Aβ42 and Tau Measures in Diagnosing Mild Cognitive Impairment in Early Onset Dementia (2022)
Journal Article
Hosseini, A. A., Brown, T., Mannino, L., Gran, B., Junaid, K., & Mukaetova-Ladinska, E. B. (2022). Clinical Utility of Cerebrospinal Fluid Aβ42 and Tau Measures in Diagnosing Mild Cognitive Impairment in Early Onset Dementia. Journal of Alzheimer's Disease, 87(2), 771-780. https://doi.org/10.3233/JAD-215650

Background: The differentiation of a preclinical or prodromal Alzheimer's disease (AD) is challenging particularly in patients with early onset Alzheimer's or related dementias (EOARD). We report our experience on diagnostic lumbar puncture to diagno... Read More about Clinical Utility of Cerebrospinal Fluid Aβ42 and Tau Measures in Diagnosing Mild Cognitive Impairment in Early Onset Dementia.

PAF-R on activated T cells: Role in the IL-23/Th17 pathway and relevance to multiple sclerosis (2020)
Journal Article
Midgley, A., Barakat, D., Braitch, M., Nichols, C., Nebozhyn, M., Edwards, L. J., …Constantinescu, C. S. (2021). PAF-R on activated T cells: Role in the IL-23/Th17 pathway and relevance to multiple sclerosis. Immunobiology, 226(1), Article 152023. https://doi.org/10.1016/j.imbio.2020.152023

© 2020 Elsevier GmbH IL-23 is a potent stimulus for Th17 cells. These cells have a distinct developmental pathway from Th1 cells induced by IL-12 and are implicated in autoimmune and inflammatory disorders including multiple sclerosis (MS). TGF-β, IL... Read More about PAF-R on activated T cells: Role in the IL-23/Th17 pathway and relevance to multiple sclerosis.

TLR2 stimulation regulates the balance between regulatory T cell and Th17 function: A novel mechanism of reduced regulatory T cell function in multiple sclerosis (2015)
Journal Article
Nyirenda, M. H., Morandi, E., Vinkemeier, U., Constantin-Teodosiu, D., Drinkwater, S., Mee, M., …Gran, B. (2015). TLR2 stimulation regulates the balance between regulatory T cell and Th17 function: A novel mechanism of reduced regulatory T cell function in multiple sclerosis. Journal of Immunology, 194(12), 5761-5774. https://doi.org/10.4049/jimmunol.1400472

CD4+ CD25hi FOXP3+ regulatory T cells (Tregs) maintain tolerance to self-Ags. Their defective function is involved in the pathogenesis of multiple sclerosis (MS), an inflammatory demyelinating disease of the CNS. However, the mechanisms of such defec... Read More about TLR2 stimulation regulates the balance between regulatory T cell and Th17 function: A novel mechanism of reduced regulatory T cell function in multiple sclerosis.

TLR2 Stimulation Regulates the Balance between Regulatory T Cell and Th17 Function: A Novel Mechanism of Reduced Regulatory T Cell Function in Multiple Sclerosis (2015)
Journal Article
Nyirenda, M. H., Morandi, E., Vinkemeier, U., Constantin-Teodosiu, D., Drinkwater, S., Mee, M., …Gran, B. (2015). TLR2 Stimulation Regulates the Balance between Regulatory T Cell and Th17 Function: A Novel Mechanism of Reduced Regulatory T Cell Function in Multiple Sclerosis. Journal of Immunology, 194(12), 5761-5774. https://doi.org/10.4049/%E2%80%8Bjimmunol.1400472

CD4+CD25hi FOXP3+ regulatory T cells (Tregs) maintain tolerance to self-Ags. Their defective function is involved in the pathogenesis of multiple sclerosis (MS), an inflammatory demyelinating disease of the CNS. However, the mechanisms of such defect... Read More about TLR2 Stimulation Regulates the Balance between Regulatory T Cell and Th17 Function: A Novel Mechanism of Reduced Regulatory T Cell Function in Multiple Sclerosis.

Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells (2015)
Journal Article
Jean-Gilles, L., Braitch, M., Latif, M. L., Aram, J., Fahey, A. J., Edwards, L. J., …Constantinescu, C. S. (2015). Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells. Acta Physiologica, 214(1), 63-74. https://doi.org/10.1111/apha.12474

© 2015 The Authors. Aims: To investigate the regulation of cannabinoid receptors CB1 and CB2 on immune cells by pro-inflammatory cytokines and its potential relevance to the inflammatory neurological disease, multiple sclerosis (MS). CB1 and CB2 sign... Read More about Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells.

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