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All Outputs (6)

SVOA Neurology Sera from Patients with Multiple Sclerosis in Relapse or Remission Affect the Blood-Brain Barrier Differently: An In vitro Study (2022)
Journal Article
Mathur, M., Gran, B., Tanasescu, R., Constantinescu, C. S., Bayraktutan, U., & Bayraktutan, U. (2022). SVOA Neurology Sera from Patients with Multiple Sclerosis in Relapse or Remission Affect the Blood-Brain Barrier Differently: An In vitro Study. SVOA Neurology, 3(5), 208-213

Background: Breakdown of the blood-brain barrier (BBB) constitutes a key step in the pathogenesis of multiple sclerosis
(MS).
Aims: To investigate whether sera from MS patients in relapse or in remission may differently affect the BBB function
and... Read More about SVOA Neurology Sera from Patients with Multiple Sclerosis in Relapse or Remission Affect the Blood-Brain Barrier Differently: An In vitro Study.

Multiple sclerosis and the risk of infection: Association of British Neurologists consensus guideline (2022)
Journal Article
Cauchi, M., Willis, M., Andrews, A., Backx, M., Brownlee, W., Ford, H. L., …Tallantyre, E. C. (2022). Multiple sclerosis and the risk of infection: Association of British Neurologists consensus guideline. Practical Neurology, 22(5), 344-357. https://doi.org/10.1136/practneurol-2022-003370

Infection in people with multiple sclerosis (MS) is of major concern, particularly for those receiving disease-modifying therapies. This article explores the risk of infection in people with MS and provides guidance - developed by Delphi consensus by... Read More about Multiple sclerosis and the risk of infection: Association of British Neurologists consensus guideline.

The Potential for EBV Vaccines to Prevent Multiple Sclerosis (2022)
Journal Article
Maple, P. A., Ascherio, A., Cohen, J. I., Cutter, G., Giovannoni, G., Shannon-Lowe, C., …Gran, B. (2022). The Potential for EBV Vaccines to Prevent Multiple Sclerosis. Frontiers in Neurology, 13, https://doi.org/10.3389/fneur.2022.887794

There is increasing evidence suggesting that Epstein-Barr virus infection is a causative factor of multiple sclerosis (MS). Epstein-Barr virus (EBV) is a human herpesvirus, Human Gammaherpesvirus 4. EBV infection shows two peaks: firstly, during earl... Read More about The Potential for EBV Vaccines to Prevent Multiple Sclerosis.

Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence (2022)
Journal Article
Gao, X., Frakich, N., Filippini, P., Edwards, L. J., Vinkemeier, U., Gran, B., Tanasescu, R., Bayraktutan, U., Colombo, S., & Constantinescu, C. S. (2022). Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence. Neuropeptides, 95, Article 102265. https://doi.org/10.1016/j.npep.2022.102265

The neuropeptide substance P (SP) mediates pain transmission, immune modulation, vasodilation and neurogenic inflammation. Its role in the peripheral nervous system has been well characterised. However, its actions on the blood-brain barrier (BBB) ar... Read More about Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence.

Clinical Utility of Cerebrospinal Fluid Aβ42 and Tau Measures in Diagnosing Mild Cognitive Impairment in Early Onset Dementia (2022)
Journal Article
Hosseini, A. A., Brown, T., Mannino, L., Gran, B., Junaid, K., & Mukaetova-Ladinska, E. B. (2022). Clinical Utility of Cerebrospinal Fluid Aβ42 and Tau Measures in Diagnosing Mild Cognitive Impairment in Early Onset Dementia. Journal of Alzheimer's Disease, 87(2), 771-780. https://doi.org/10.3233/JAD-215650

Background: The differentiation of a preclinical or prodromal Alzheimer's disease (AD) is challenging particularly in patients with early onset Alzheimer's or related dementias (EOARD). We report our experience on diagnostic lumbar puncture to diagno... Read More about Clinical Utility of Cerebrospinal Fluid Aβ42 and Tau Measures in Diagnosing Mild Cognitive Impairment in Early Onset Dementia.