All Outputs (7)

Ocrelizumab B cell depletion has no effect on HERV RNA expression in PBMC in MS patients (2024)
Journal Article
Tarlinton, R., Tanasescu, R., Shannon-Lowe, C., & Gran, B. (2024). Ocrelizumab B cell depletion has no effect on HERV RNA expression in PBMC in MS patients. Multiple Sclerosis and Related Disorders, 86, Article 105597. https://doi.org/10.1016/j.msard.2024.105597

Background
Epstein barr virus (EBV) infection of B cells is now understood to be one of the triggering events for the development of Multiple Sclerosis (MS), a progressive immune-mediated disease of the central nervous system. EBV infection is also... Read More about Ocrelizumab B cell depletion has no effect on HERV RNA expression in PBMC in MS patients.

Investigating the Effect of Cigarette Smoking on Serum Uric Acid Levels in Multiple Sclerosis Patients: A Cross Sectional Study (2023)
Journal Article
Alrouji, M., Manouchehrinia, A., Aram, J., Alotaibi, A., Alhajlah, S., Almuhanna, Y., …Constantinescu, C. S. (2023). Investigating the Effect of Cigarette Smoking on Serum Uric Acid Levels in Multiple Sclerosis Patients: A Cross Sectional Study. Brain Sciences, 13(5), Article 800. https://doi.org/10.3390/brainsci13050800

Objectives: The present study is aimed at determining the effect of cigarette smoking (CS) on serum uric acid (UA) levels quantitatively before and after smoking cessation among people with MS (pwMS). Additionally, a possible correlation between UA l... Read More about Investigating the Effect of Cigarette Smoking on Serum Uric Acid Levels in Multiple Sclerosis Patients: A Cross Sectional Study.

SVOA Neurology Sera from Patients with Multiple Sclerosis in Relapse or Remission Affect the Blood-Brain Barrier Differently: An In vitro Study (2022)
Journal Article
Mathur, M., Gran, B., Tanasescu, R., Constantinescu, C. S., Bayraktutan, U., & Bayraktutan, U. (2022). SVOA Neurology Sera from Patients with Multiple Sclerosis in Relapse or Remission Affect the Blood-Brain Barrier Differently: An In vitro Study. SVOA Neurology, 3(5), 208-213

Background: Breakdown of the blood-brain barrier (BBB) constitutes a key step in the pathogenesis of multiple sclerosis
(MS).
Aims: To investigate whether sera from MS patients in relapse or in remission may differently affect the BBB function
and... Read More about SVOA Neurology Sera from Patients with Multiple Sclerosis in Relapse or Remission Affect the Blood-Brain Barrier Differently: An In vitro Study.

Multiple sclerosis and the risk of infection: Association of British Neurologists consensus guideline (2022)
Journal Article
Cauchi, M., Willis, M., Andrews, A., Backx, M., Brownlee, W., Ford, H. L., …Tallantyre, E. C. (2022). Multiple sclerosis and the risk of infection: Association of British Neurologists consensus guideline. Practical Neurology, 22(5), 344-357. https://doi.org/10.1136/practneurol-2022-003370

Infection in people with multiple sclerosis (MS) is of major concern, particularly for those receiving disease-modifying therapies. This article explores the risk of infection in people with MS and provides guidance - developed by Delphi consensus by... Read More about Multiple sclerosis and the risk of infection: Association of British Neurologists consensus guideline.

Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence (2022)
Journal Article
Gao, X., Frakich, N., Filippini, P., Edwards, L. J., Vinkemeier, U., Gran, B., Tanasescu, R., Bayraktutan, U., Colombo, S., & Constantinescu, C. S. (2022). Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence. Neuropeptides, 95, Article 102265. https://doi.org/10.1016/j.npep.2022.102265

The neuropeptide substance P (SP) mediates pain transmission, immune modulation, vasodilation and neurogenic inflammation. Its role in the peripheral nervous system has been well characterised. However, its actions on the blood-brain barrier (BBB) ar... Read More about Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence.

Clinical Utility of Cerebrospinal Fluid Aβ42 and Tau Measures in Diagnosing Mild Cognitive Impairment in Early Onset Dementia (2022)
Journal Article
Hosseini, A. A., Brown, T., Mannino, L., Gran, B., Junaid, K., & Mukaetova-Ladinska, E. B. (2022). Clinical Utility of Cerebrospinal Fluid Aβ42 and Tau Measures in Diagnosing Mild Cognitive Impairment in Early Onset Dementia. Journal of Alzheimer's Disease, 87(2), 771-780. https://doi.org/10.3233/JAD-215650

Background: The differentiation of a preclinical or prodromal Alzheimer's disease (AD) is challenging particularly in patients with early onset Alzheimer's or related dementias (EOARD). We report our experience on diagnostic lumbar puncture to diagno... Read More about Clinical Utility of Cerebrospinal Fluid Aβ42 and Tau Measures in Diagnosing Mild Cognitive Impairment in Early Onset Dementia.

PAF-R on activated T cells: Role in the IL-23/Th17 pathway and relevance to multiple sclerosis (2020)
Journal Article
Midgley, A., Barakat, D., Braitch, M., Nichols, C., Nebozhyn, M., Edwards, L. J., …Constantinescu, C. S. (2021). PAF-R on activated T cells: Role in the IL-23/Th17 pathway and relevance to multiple sclerosis. Immunobiology, 226(1), Article 152023. https://doi.org/10.1016/j.imbio.2020.152023

© 2020 Elsevier GmbH IL-23 is a potent stimulus for Th17 cells. These cells have a distinct developmental pathway from Th1 cells induced by IL-12 and are implicated in autoimmune and inflammatory disorders including multiple sclerosis (MS). TGF-β, IL... Read More about PAF-R on activated T cells: Role in the IL-23/Th17 pathway and relevance to multiple sclerosis.