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All Outputs (37)

Long-stay in forensic-psychiatric care in the UK (2018)
Journal Article
Hare Duke, L., Furtado, V., Guo, B., & Völlm, B. A. (in press). Long-stay in forensic-psychiatric care in the UK. Social Psychiatry and Psychiatric Epidemiology, https://doi.org/10.1007/s00127-017-1473-y

Purpose: Forensic services provide care for mentally disordered offenders. In England this is provided at three levels of security – low, medium and high. Significant number of patients within these settings remain detained for protracted periods of... Read More about Long-stay in forensic-psychiatric care in the UK.

Cost-effectiveness of a preferred intensity exercise programme for young people with depression compared with treatment as usual: An economic evaluation alongside a clinical trial in the UK (2017)
Journal Article
Carter, T., Turner, D., Sach, T., Guo, B., & Callaghan, P. (2017). Cost-effectiveness of a preferred intensity exercise programme for young people with depression compared with treatment as usual: An economic evaluation alongside a clinical trial in the UK. BMJ Open, 7(11), e016211. https://doi.org/10.1136/bmjopen-2017-016211

© 2017 BMJ Publishing Group. All Rights Reserved. Objectives To assess the cost-effectiveness of preferred intensity exercise programme for young people with depression compared with a treatment as usual control group. Design A ‘within trial’ cost-ef... Read More about Cost-effectiveness of a preferred intensity exercise programme for young people with depression compared with treatment as usual: An economic evaluation alongside a clinical trial in the UK.

The effects of using the PReDicT Test to guide the antidepressant treatment of depressed patients: study protocol for a randomised controlled trial (2017)
Journal Article
Kingslake, J., Dias, R., Dawson, G. R., Simon, J., Goodwin, G. M., Harmer, C. J., …Browning, M. (2017). The effects of using the PReDicT Test to guide the antidepressant treatment of depressed patients: study protocol for a randomised controlled trial. Trials, 18(1), Article 558. https://doi.org/10.1186/s13063-017-2247-2

Background

Antidepressant medication is commonly used to treat depression. However, many patients do not respond to the first medication prescribed and improvements in symptoms are generally only detectable by clinicians 4–6 weeks after the medica... Read More about The effects of using the PReDicT Test to guide the antidepressant treatment of depressed patients: study protocol for a randomised controlled trial.

Clinical and cost-effectiveness of adapted cognitive behaviour therapy for non-cardiac chest pain: a multicentre, randomised controlled trial (2017)
Journal Article
Tyrer, P., Tyrer, H., Morriss, R., Crawford, M., Cooper, S., Yang, M., …Barrett, B. (in press). Clinical and cost-effectiveness of adapted cognitive behaviour therapy for non-cardiac chest pain: a multicentre, randomised controlled trial. Open Heart, 4(1), Article e000582. https://doi.org/10.1136/openhrt-2016-000582

Objective: To investigate the cost-effectiveness of a modified form of cognitive behaviour therapy for recurrent non-cardiac chest pain.
Methods: We tested the effectiveness and cost-effectiveness of a modified form of cognitive behaviour therapy fo... Read More about Clinical and cost-effectiveness of adapted cognitive behaviour therapy for non-cardiac chest pain: a multicentre, randomised controlled trial.

Factor structure and longitudinal measurement invariance of PHQ-9 for specialist mental health care patients with persistent major depressive disorder: Exploratory Structural Equation Modelling (2017)
Journal Article
Guo, B., Kaylor-Hughes, C., Garland, A., Nixon, N., Sweeney, T., Simpson, S., …Morriss, R. (2017). Factor structure and longitudinal measurement invariance of PHQ-9 for specialist mental health care patients with persistent major depressive disorder: Exploratory Structural Equation Modelling. Journal of Affective Disorders, 219, 1-8. https://doi.org/10.1016/j.jad.2017.05.020

Background: The Patient Health Questionnaire-9 (PHQ-9) is a widely used instrument for measuring levels of depression in patients in clinical practice and academic research; its factor structure has been investigated in various samples, with limited... Read More about Factor structure and longitudinal measurement invariance of PHQ-9 for specialist mental health care patients with persistent major depressive disorder: Exploratory Structural Equation Modelling.

Feasibility of an online intervention (STAK-D) to promote physical activity in children with type 1 diabetes: protocol for a randomised controlled trial (2016)
Journal Article
Blake, H., Quirk, H., Leighton, P., Randell, T., Greening, J., Guo, B., & Glazebrook, C. (2016). Feasibility of an online intervention (STAK-D) to promote physical activity in children with type 1 diabetes: protocol for a randomised controlled trial. Trials, 17(283), https://doi.org/10.1186/s13063-016-1719-0

Background: Regular physical activity has important health benefits for children with type 1 diabetes mellitus (T1DM), yet children and their parents face barriers to participation such as lack of self-efficacy or concerns around hypoglycaemia. Multi... Read More about Feasibility of an online intervention (STAK-D) to promote physical activity in children with type 1 diabetes: protocol for a randomised controlled trial.

Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial (2016)
Journal Article
Patel, S., Malins, S., Guo, B., James, M., Kai, J., Kaylor-Hughes, C., …Morriss, R. K. (2016). Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial. BJPsych Open, 2, https://doi.org/10.1192/bjpo.bp.115.002220

Background
Health anxiety and medically unexplained symptoms cost the National Health Service (NHS) an estimated £3 billion per year in unnecessary costs with little evidence of patient benefit. Effective treatment is rarely taken up due to issues s... Read More about Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial.

Innovations in practice: an objective measure of attention, impulsivity and activity reduces time to confirm attention deficit/hyperactivity disorder diagnosis in children: a completed audit cycle (2016)
Journal Article
Hall, C. L., Selby, K., Guo, B., Valentine, A. Z., Walker, G. M., & Hollis, C. (2016). Innovations in practice: an objective measure of attention, impulsivity and activity reduces time to confirm attention deficit/hyperactivity disorder diagnosis in children: a completed audit cycle. Child and Adolescent Mental Health, 21(3), 175-178. https://doi.org/10.1111/camh.12140

Background

Diagnosing attention deficit/hyperactivity disorder (ADHD) in children and young people typically relies on clinical observation and subjective parent, teacher and self-reports. The subjective nature of reports combined with contradicto... Read More about Innovations in practice: an objective measure of attention, impulsivity and activity reduces time to confirm attention deficit/hyperactivity disorder diagnosis in children: a completed audit cycle.

Urine tests for Down's syndrome screening (2015)
Journal Article
Alldred, S. K., Guo, B., Takwoingi, Y., Pennant, M., Wisniewski, S., Deeks, J. J., …Alldred, S. K. (2015). Urine tests for Down's syndrome screening. Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD011984

Background

Down's syndrome occurs when a person has three copies of chromosome 21, or the specific area of chromosome 21 implicated in causing Down's syndrome, rather than two. It is the commonest congenital cause of mental disability and also lea... Read More about Urine tests for Down's syndrome screening.

Cognitive behaviour therapy for non-cardiac pain in the chest (COPIC): a multicentre randomized controlled trial with economic evaluation (2015)
Journal Article
Tyrer, P., Tyrer, H., Cooper, S., Barrett, B., Kings, S., Lazarevic, V., …Crawford, M. (2015). Cognitive behaviour therapy for non-cardiac pain in the chest (COPIC): a multicentre randomized controlled trial with economic evaluation. BMC Psychology, 3(41), https://doi.org/10.1186/s40359-015-0099-7

Background

Most patients with chest pain have nothing wrong with their cardiac function. Psychological forms of treatment for this condition are more likely to be successful than others.

Methods/design

A two-arm parallel controlled randomize... Read More about Cognitive behaviour therapy for non-cardiac pain in the chest (COPIC): a multicentre randomized controlled trial with economic evaluation.

Preferred intensity exercise for adolescents receiving treatment for depression: A pragmatic randomised controlled trial (2015)
Journal Article
Carter, T., Guo, B., Turner, D., Morres, I., Khalil, E., Brighton, E., …Callaghan, P. (2015). Preferred intensity exercise for adolescents receiving treatment for depression: A pragmatic randomised controlled trial. BMC Psychiatry, 15(1), Article 247. https://doi.org/10.1186/s12888-015-0638-z

© 2015 Carter et al. Background: Exercise has been shown to be effective in treating depression, but trials testing the effect of exercise for depressed adolescents utilising mental health services are rare. The aim of this study was to determine the... Read More about Preferred intensity exercise for adolescents receiving treatment for depression: A pragmatic randomised controlled trial.

Performance of methods for meta-analysis of diagnostic test accuracy with few studies or sparse data (2015)
Journal Article
Takwoingi, Y., Guo, B., Riley, R. D., & Deeks, J. J. (2015). Performance of methods for meta-analysis of diagnostic test accuracy with few studies or sparse data. Statistical Methods in Medical Research, https://doi.org/10.1177/0962280215592269

Hierarchical models such as the bivariate and hierarchical summary receiver operating characteristic (HSROC) models are recommended for meta-analysis of test accuracy studies. These models are challenging to fit when there are few studies and/or spar... Read More about Performance of methods for meta-analysis of diagnostic test accuracy with few studies or sparse data.

First trimester serum tests for Down's syndrome screening (2015)
Journal Article
Alldred, S. K., Takwoingi, Y., Guo, B., Pennant, M., Deeks, J. J., Neilson, J. P., & Alfirevic, Z. (2015). First trimester serum tests for Down's syndrome screening. Cochrane Database of Systematic Reviews, 11, Article CD011975. https://doi.org/10.1002/14651858.CD011975

Background

Down's syndrome occurs when a person has three, rather than two copies of chromosome 21; or the specific area of chromosome 21 implicated in causing Down's syndrome. It is the commonest congenital cause of mental disability and also lea... Read More about First trimester serum tests for Down's syndrome screening.

Individual participant data meta-analyses should not ignore clustering (2013)
Journal Article
Abo-Zaid, G., Guo, B., Deeks, J. J., Debray, T. P., Steyerberg, E. W., Moons, K. G., & Riley, R. D. (2013). Individual participant data meta-analyses should not ignore clustering. Journal of Clinical Epidemiology, 66(8), Article 865-873.e4. https://doi.org/10.1016/j.jclinepi.2012.12.017

Objectives

Individual participant data (IPD) meta-analyses often analyze their IPD as if coming from a single study. We compare this approach with analyses that rather account for clustering of patients within studies.

Study Design and Setting... Read More about Individual participant data meta-analyses should not ignore clustering.

Second trimester serum tests for Down's Syndrome screening (2012)
Journal Article
Alldred, S. K., Deeks, J. J., Guo, B., Neilson, J. P., & Alfirevic, Z. (2012). Second trimester serum tests for Down's Syndrome screening. Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD009925

Background

Down's syndrome occurs when a person has three copies of chromosome 21 - or the specific area of chromosome 21 implicated in causing Down's syndrome - rather than two. It is the commonest congenital cause of mental retardation. Noninvas... Read More about Second trimester serum tests for Down's Syndrome screening.

SKIP (Supporting Kids with diabetes In Physical activity): Feasibility of a randomised controlled trial of a digital intervention for 9-12 year olds with type 1 diabetes mellitus
Presentation / Conference Contribution
Blake, H., Knox, E., Randell, T., Leighton, P., Guo, B., Greening, J., Bethan Davies, E., Amor, L., & Glazebrook, C. (2019, October). SKIP (Supporting Kids with diabetes In Physical activity): Feasibility of a randomised controlled trial of a digital intervention for 9-12 year olds with type 1 diabetes mellitus. Presented at 5th International Clinical Trials Methodology Conference (ICTMC 2019), Brighton, UK

Introduction: Physical activity is important for children with type 1 diabetes mellitus (T1DM) but it is unclear whether interventions delivered online are feasible, acceptable to patients and efficacious. The aim was to assess the feasibility and ac... Read More about SKIP (Supporting Kids with diabetes In Physical activity): Feasibility of a randomised controlled trial of a digital intervention for 9-12 year olds with type 1 diabetes mellitus.