In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss

Chernyavsky, Igor L.; Russell, Richard J.; Saunders, Ruth M.; Morris, Gavin E.; Berair, Rachid; Singapuri, Amisha; Chachi, Latifa; Mansur, Adel H.; Howarth, Peter H.; Dennison, Paddy; Chaudhuri, Rekha; Bicknell, Stephen; Rose, Felicity R A.J.; Siddiqui, Salman; Brook, Bindi S.; Brightling, Christopher E.

doi:10.1183/13993003.01680-2017

All Outputs (3)

Effect of loading history on airway smooth muscle cell-matrix adhesions (2018)
Journal Article
Irons, L., Owen, M. R., O'Dea, R. D., & Brook, B. S. (2018). Effect of loading history on airway smooth muscle cell-matrix adhesions. Biophysical Journal, 114(11), 2679-2690. https://doi.org/10.1016/j.bpj.2018.04.026

Integrin-mediated adhesions between airway smooth muscle (ASM) cells and the extracellular matrix (ECM) regulate how contractile forces generated within the cell are transmitted to its external environment. Environmental cues are known to influence t... Read More about Effect of loading history on airway smooth muscle cell-matrix adhesions.

A multiphase multiscale model for nutrient limited tissue growth (2018)
Journal Article
Holden, E., Collis, J., Brook, B. S., & O'Dea, R. D. (2018). A multiphase multiscale model for nutrient limited tissue growth. ANZIAM Journal, 59(4), https://doi.org/10.1017/S1446181118000044

In this work, an effective macroscale description is derived for the growth of tissue on a porous scaffold. A multiphase model is employed to describe the tissue dynamics; linearisation to facilitate a multiple-scale homogenisation provides an effect... Read More about A multiphase multiscale model for nutrient limited tissue growth.

In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss (2018)
Journal Article
Chernyavsky, I. L., Russell, R. J., Saunders, R. M., Morris, G. E., Berair, R., Singapuri, A., Chachi, L., Mansur, A. H., Howarth, P. H., Dennison, P., Chaudhuri, R., Bicknell, S., Rose, F. R. A., Siddiqui, S., Brook, B. S., & Brightling, C. E. (2018). In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss. European Respiratory Journal, 51(5), Article 1701680. https://doi.org/10.1183/13993003.01680-2017

Bronchial thermoplasty is a treatment for asthma. Whether during thermoplasty the airway wall fraction exposed to temperatures necessary to affect cells is sufficient to explain its histopathological impact is unclear.
Airway smooth muscle and bronc... Read More about In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss.