MicroRNA biogenesis is broadly disrupted by inhibition of the splicing factor SF3B1
(2024)
Journal Article
Downie Ruiz Velasco, A., Parsons, A. L., Heatley, M. C., Martin, A. R., Smart, A. D., Shah, N., & Jopling, C. L. (2024). MicroRNA biogenesis is broadly disrupted by inhibition of the splicing factor SF3B1. Nucleic Acids Research, 52(15), 9210-9229. https://doi.org/10.1093/nar/gkae505
In animals, microRNA (miRNA) biogenesis begins with cotranscriptional cleavage of the primary (pri-)miRNA by the Microprocessor complex. Cotranscriptional splicing has been shown to influence Microprocessor cleavage when miRNAs are hosted in introns... Read More about MicroRNA biogenesis is broadly disrupted by inhibition of the splicing factor SF3B1.