Multi-omic approach identifies hypoxic tumor-associated myeloid cells that drive immunobiology of high-risk pediatric ependymoma.

Griesinger, Andrea M.; Riemondy, Kent; Eswaran, Nithyashri; Donson, Andrew M.; Willard, Nicholas; Prince, Eric W.; Paine, Simon M. L.; Bowes, Georgia; Rheaume, John; Chapman, Rebecca J.; Ramage, Judith; Jackson, Andrew; Grundy, Richard G.; Foreman, Nicholas K.; Ritzmann, Timothy A

doi:10.1016/j.isci.2023.107585

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Multi-omic approach identifies hypoxic tumor-associated myeloid cells that drive immunobiology of high-risk pediatric ependymoma. (2023)
Journal Article
Griesinger, A. M., Riemondy, K., Eswaran, N., Donson, A. M., Willard, N., Prince, E. W., …Ritzmann, T. A. (2023). Multi-omic approach identifies hypoxic tumor-associated myeloid cells that drive immunobiology of high-risk pediatric ependymoma. iScience, 26(9), Article 107585. https://doi.org/10.1016/j.isci.2023.107585

Ependymoma (EPN) is a devastating childhood brain tumor. Single-cell analyses have illustrated the cellular heterogeneity of EPN tumors, identifying multiple neoplastic cell states including a mesenchymal-differentiated subpopulation which characteri... Read More about Multi-omic approach identifies hypoxic tumor-associated myeloid cells that drive immunobiology of high-risk pediatric ependymoma..