2-Alkyl-4-quinolone quorum sensing molecules are biomarkers for culture-independent Pseudomonas aeruginosa burden in adults with cystic fibrosis

Zain, Nur Masirah M.; Webb, Karmel; Stewart, Iain; Halliday, Nigel; Barrett, David A.; Nash, Edward F.; Whitehouse, Joanna L.; Honeybourne, David; Smyth, Alan R.; Forrester, Douglas L.; Knox, Alan J.; Williams, Paul; Fogarty, Andrew; Cámara, Miguel; Bruce, Kenneth D.; Barr, Helen L.

doi:10.1099/jmm.0.001420

All Outputs (9)

Prospective study of exposure to smoking imagery in films and changes in susceptibility to smoking in a cohort of school students in Southern India (2024)
Journal Article
Kamath, V. G., Kulkarni, M. M., Kamath, A., Lewis, S., Bogdanovica, I., Bains, M., …Britton, J. (2024). Prospective study of exposure to smoking imagery in films and changes in susceptibility to smoking in a cohort of school students in Southern India. Tobacco Induced Diseases, 22(May), Article 88. https://doi.org/10.18332/tid/178442

INTRODUCTION India has unique tobacco-free film and TV rules designed to prevent tobacco uptake. In this study, we examined the potential influence of exposure to smoking imagery in regionally famous films, on susceptibility to smoke in teenagers enr... Read More about Prospective study of exposure to smoking imagery in films and changes in susceptibility to smoking in a cohort of school students in Southern India.

A requirement for the use of supplementary oxygen to guide medical treatment decisions may introduce bias against non-white individuals (2024)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., Cruickshank, S., Hammond-Pears, S., Shaw, D., Card, T. R., & Fogarty, A. W. (in press). A requirement for the use of supplementary oxygen to guide medical treatment decisions may introduce bias against non-white individuals. European Respiratory Journal, Article 2302320. https://doi.org/10.1183/13993003.02320-2023

Prevalence, regional patterns and socio-demographic factors associated with poly-tobacco use in India: A secondary data analysis (2024)
Journal Article
Bantwal, P., Kulkarni, M. M., Kamath, V. G., Naik, A. K., Fogarty, A. W., Dhar, M., & Ahankari, A. S. (2024). Prevalence, regional patterns and socio-demographic factors associated with poly-tobacco use in India: A secondary data analysis. PLOS Global Public Health, 4(3), Article e0002999. https://doi.org/10.1371/journal.pgph.0002999

Background: Tobacco use is associated with early, intermediate and long-term complications throughout the life course. With an influx of newer products containing nicotine, poly-tobacco use is slowly emerging as a public health concern, that is defin... Read More about Prevalence, regional patterns and socio-demographic factors associated with poly-tobacco use in India: A secondary data analysis.

The association between living alone, loneliness and suicide mortality and effect modification by age: A case:control study (2024)
Journal Article
Alothman, D., Lewis, S., Card, T., Tyrrell, E., & Fogarty, A. W. (2024). The association between living alone, loneliness and suicide mortality and effect modification by age: A case:control study. Journal of Affective Disorders, 352, 278-280. https://doi.org/10.1016/j.jad.2024.02.047

Background: Social isolation is a potentially reversible risk factor for suicide. Methods: A matched case control study design was used. The study population was from England and identified from an electronic primary case database with linkage to a s... Read More about The association between living alone, loneliness and suicide mortality and effect modification by age: A case:control study.

Evaluation of common prescription analgesics and adjuvant analgesics as markers of suicide risk: a longitudinal population-based study in England (2023)
Journal Article
Alothman, D., Tyrrell, E., Lewis, S., Card, T., & Fogarty, A. W. (2023). Evaluation of common prescription analgesics and adjuvant analgesics as markers of suicide risk: a longitudinal population-based study in England. The Lancet Regional Health Europe, 32, Article 100695. https://doi.org/10.1016/j.lanepe.2023.100695

Background: Analgesics prescriptions may provide a marker for identifying individuals at higher risk of suicide. In particular, awareness of which analgesics are implicated may help clinicians assess and modify risk. Method: A case–control study in E... Read More about Evaluation of common prescription analgesics and adjuvant analgesics as markers of suicide risk: a longitudinal population-based study in England.

Prevalence and risk factors for tobacco, khat and alcohol consumption among high school students in Ethiopia (2023)
Journal Article
Hirpa, S., Fogarty, A. W., Addissie, A., Bauld, L., Frese, T., Unverzagt, S., …Deressa, W. (2023). Prevalence and risk factors for tobacco, khat and alcohol consumption among high school students in Ethiopia. BMC Public Health, 23, Article 226. https://doi.org/10.1186/s12889-023-15088-x

Background: Tobacco, khat, alcohol and marijuana are the main risk factors for non-communicable diseases. There are limited studies on substance use in Ethiopia, especially among secondary school students. This study aims to determine the epidemiol... Read More about Prevalence and risk factors for tobacco, khat and alcohol consumption among high school students in Ethiopia.

Risk of Suicide After Dementia Diagnosis (2022)
Journal Article
Alothman, D., Card, T., Lewis, S., Tyrrell, E., Fogarty, A. W., & Marshall, C. R. (2022). Risk of Suicide After Dementia Diagnosis. JAMA Neurology, 79(11), 1148-1154. https://doi.org/10.1001/jamaneurol.2022.3094

Importance: Patients with dementia may be at an increased suicide risk. Identifying groups at greatest risk of suicide would support targeted risk reduction efforts by clinical dementia services. Objectives: To examine the association between a d... Read More about Risk of Suicide After Dementia Diagnosis.

Porphyromonas pasteri and Prevotella nanceiensis in the sputum microbiota are associated with increased decline in lung function in individuals with cystic fibrosis (2022)
Journal Article
Webb, K., Zain, N. M. M., Stewart, I., Fogarty, A., Nash, E. F., Whitehouse, J. L., Smyth, A. R., Lilley, A. K., Knox, A., Williams, P., Cámara, M., Bruce, K., & Barr, H. L. (2022). Porphyromonas pasteri and Prevotella nanceiensis in the sputum microbiota are associated with increased decline in lung function in individuals with cystic fibrosis. Journal of Medical Microbiology, 71(2), Article 001481. https://doi.org/10.1099/jmm.0.001481

Although anaerobic bacteria exist in abundance in cystic fibrosis (CF) airways, their role in disease progression is poorly understood. We hypothesized that the presence and relative abundance of the most prevalent, live, anaerobic bacteria in sputum... Read More about Porphyromonas pasteri and Prevotella nanceiensis in the sputum microbiota are associated with increased decline in lung function in individuals with cystic fibrosis.

2-Alkyl-4-quinolone quorum sensing molecules are biomarkers for culture-independent Pseudomonas aeruginosa burden in adults with cystic fibrosis (2021)
Journal Article
Zain, N. M. M., Webb, K., Stewart, I., Halliday, N., Barrett, D. A., Nash, E. F., Whitehouse, J. L., Honeybourne, D., Smyth, A. R., Forrester, D. L., Knox, A. J., Williams, P., Fogarty, A., Cámara, M., Bruce, K. D., & Barr, H. L. (2021). 2-Alkyl-4-quinolone quorum sensing molecules are biomarkers for culture-independent Pseudomonas aeruginosa burden in adults with cystic fibrosis. Journal of Medical Microbiology, 70(10), https://doi.org/10.1099/jmm.0.001420

Introduction. Pseudomonas aeruginosa produces quorum sensing signalling molecules including 2-alkyl-4-quinolones (AQs), which regulate virulence factor production in the cystic fibrosis (CF) airways. Hypothesis/Gap statement. Culture can lead to cond... Read More about 2-Alkyl-4-quinolone quorum sensing molecules are biomarkers for culture-independent Pseudomonas aeruginosa burden in adults with cystic fibrosis.