IL-15 promotes human myogenesis and mitigates the detrimental effects of TNFα on myotube development
(2017)
Journal Article
O’Leary, M. F., Wallace, G. R., Bennett, A. J., Tsintzas, K., & Jones, S. W. (in press). IL-15 promotes human myogenesis and mitigates the detrimental effects of TNFα on myotube development. Scientific Reports, 7(1), Article 12997. https://doi.org/10.1038/s41598-017-13479-w
Studies in murine cell lines and in mouse models suggest that IL-15 promotes myogenesis and may protect against the inflammation-mediated skeletal muscle atrophy which occurs in sarcopenia and cachexia. The effects of IL-15 on human skeletal muscle g... Read More about IL-15 promotes human myogenesis and mitigates the detrimental effects of TNFα on myotube development.