SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ
(2011)
Journal Article
Begitt, A., Droescher, M., Knobeloch, K.-P., & Vinkemeier, U. (2011). SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ. Blood, 118(4), https://doi.org/10.1182/blood-2011-04-347930
The biologic effects of IFNγ are mediated by the transcription factor STAT1. The activity of STAT1 is inhibited by small ubiquitin-like modifier (SUMO) conjugation. This occurs both directly through decreasing STAT1 tyrosine phosphorylation and indir... Read More about SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ.