All Outputs (2)

Computational investigation of cis-1,4-polyisoprene binding to the latex-clearing protein LcpK30 (2024)
Journal Article
Abu Hassan, A., Hanževački, M., & Pordea, A. (2024). Computational investigation of cis-1,4-polyisoprene binding to the latex-clearing protein LcpK30. PLoS ONE, 19(5), Article e0302398. https://doi.org/10.1371/journal.pone.0302398

Latex clearing proteins (Lcps) catalyze the oxidative cleavage of the C = C bonds in cis-1,4-polyisoprene (natural rubber), producing oligomeric compounds that can be repurposed to other materials. The active catalytic site of Lcps is buried inside t... Read More about Computational investigation of cis-1,4-polyisoprene binding to the latex-clearing protein LcpK30.

Encapsulation of copper phenanthroline within horse spleen apoferritin: characterisation, cytotoxic activity and ability to retain temozolomide (2024)
Journal Article
Cassioli, M. L., Fay, M., Turyanska, L., Bradshaw, T. D., Thomas, N. R., & Pordea, A. (2024). Encapsulation of copper phenanthroline within horse spleen apoferritin: characterisation, cytotoxic activity and ability to retain temozolomide. RSC Advances, 14(20), 14008-14016. https://doi.org/10.1039/d3ra07430g

Protein capsules are promising drug delivery vehicles for cancer research therapies. Apoferritin (AFt) is a self-assembling 12 nm diameter hollow nanocage with many desirable features for drug delivery, however, control of drug retention inside the p... Read More about Encapsulation of copper phenanthroline within horse spleen apoferritin: characterisation, cytotoxic activity and ability to retain temozolomide.