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All Outputs (6)

Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients (2024)
Journal Article
Kouraki, A., Zheng, A. S., Miller, S., Kelly, A., Ashraf, W., Bazzani, D., Bonadiman, A., Tonidandel, G., Bolzan, M., Vijay, A., Nightingale, J., Menni, C., Ollivere, B. J., & Valdes, A. M. (2024). Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients. iScience, 27(9), Article 110783. https://doi.org/10.1016/j.isci.2024.110783

We investigated changes in microbiome composition and abundance of antimicrobial resistance (AMR) genes post-antibiotic treatment in severe trauma patients. Shotgun sequencing revealed beta diversity (Bray-Curtis) differences between 16 hospitalized... Read More about Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients.

Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial (2024)
Journal Article
Kouraki, A., Nogal, A., Nocun, W., Louca, P., Vijay, A., Wong, K., Michelotti, G. A., Menni, C., & Valdes, A. M. (2024). Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial. Metabolites, 14(6), Article 311. https://doi.org/10.3390/metabo14060311

Metabolomics can uncover physiological responses to prebiotic fibre and omega-3 fatty acid supplements with known health benefits and identify response-specific metabolites. We profiled 534 stool and 799 serum metabolites in 64 healthy adults followi... Read More about Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial.

The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery (2023)
Journal Article
Louca, P., Meijnikman, A. S., Nogal, A., Asnicar, F., Attaye, I., Vijay, A., …Menni, C. (2023). The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery. Cell Reports Medicine, 4(4), Article 100993. https://doi.org/10.1016/j.xcrm.2023.100993

Primary and secondary bile acids (BAs) influence metabolism and inflammation, and the gut microbiome modulates levels of BAs. We systematically explore the host genetic, gut microbial, and habitual dietary contribution to a panel of 19 serum and 15 s... Read More about The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery.

Serum Metabolome Analysis Identified Amino-Acid Metabolism Associated With Pain in People With Symptomatic Knee Osteoarthritis – A Cross-Sectional Study (2023)
Journal Article
Mehta, O., Vijay, A., Gohir, S. A., Kelly, T., Zhang, W., Doherty, M., …Valdes, A. M. (2023). Serum Metabolome Analysis Identified Amino-Acid Metabolism Associated With Pain in People With Symptomatic Knee Osteoarthritis – A Cross-Sectional Study. Journal of Pain, https://doi.org/10.1016/j.jpain.2023.02.023

Osteoarthritis (OA) is the most common arthritis affecting synovial joints such as knees and hips of millions of people globally. Usage-related joint pain and reduced function are the most common symptoms experienced by people with OA. To improve pai... Read More about Serum Metabolome Analysis Identified Amino-Acid Metabolism Associated With Pain in People With Symptomatic Knee Osteoarthritis – A Cross-Sectional Study.

Reproducible microbiome composition signatures of anxiety and depressive symptoms (2023)
Journal Article
Kouraki, A., Kelly, A., Vijay, A., Gohir, S., Astbury, S., Georgopoulos, V., …Valdes, A. M. (2023). Reproducible microbiome composition signatures of anxiety and depressive symptoms. Computational and Structural Biotechnology Journal, 21, 5326-5336. https://doi.org/10.1016/j.csbj.2023.10.035

The gut microbiome is a significant contributor to mental health, with growing evidence linking its composition to anxiety and depressive disorders. Gut microbiome composition is associated with signs of anxiety and depression both in clinically diag... Read More about Reproducible microbiome composition signatures of anxiety and depressive symptoms.