All Outputs (6)

Reliable computational quantification of liver fibrosis is compromised by inherent staining variation (2021)
Journal Article
Astbury, S., Grove, J. I., Dorward, D. A., Guha, I. N., Fallowfield, J. A., & Kendall, T. J. (2021). Reliable computational quantification of liver fibrosis is compromised by inherent staining variation. Journal of Pathology: Clinical Research, 7(5), 471-481. https://doi.org/10.1002/cjp2.227

Biopsy remains the gold standard measure for staging liver disease, both to inform prognosis and to assess the response to a given treatment. Semiquantitative scores such as the Ishak fibrosis score are used for evaluation. These scores are utilised... Read More about Reliable computational quantification of liver fibrosis is compromised by inherent staining variation.

In severe alcoholic hepatitis, serum cytokeratin-18 fragments are diagnostic, prognostic and theragnostic biomarkers (2020)
Journal Article
Atkinson, S. R., Grove, J. I., Liebig, S., Astbury, S., Vergis, N., Goldin, R., …Aithal, G. P. (2020). In severe alcoholic hepatitis, serum cytokeratin-18 fragments are diagnostic, prognostic and theragnostic biomarkers. American Journal of Gastroenterology, 115(11), 1857-1868. https://doi.org/10.14309/ajg.0000000000000912

INTRODUCTION:

Up to 40% of patients with severe alcoholic hepatitis (AH) die within 6 months of presentation, making prompt diagnosis and appropriate treatment essential. We determined the associations between serum keratin-18 (K18) and histologi... Read More about In severe alcoholic hepatitis, serum cytokeratin-18 fragments are diagnostic, prognostic and theragnostic biomarkers.

Genetic variation in HSD17B13 reduces the risk of developing cirrhosis and hepatocellular carcinoma in alcohol misusers (2020)
Journal Article
Stickel, F., Lutz, P., Buch, S., Nischalke, H. D., Silva, I., Rausch, V., …Morgan, M. Y. (2020). Genetic variation in HSD17B13 reduces the risk of developing cirrhosis and hepatocellular carcinoma in alcohol misusers. Hepatology, 72(1), 88-102. https://doi.org/10.1002/hep.30996

Background & Aims:
Carriage of rs738409:G in patatin-like phospholipase domain-containing 3 (PNPLA3) is associated with an increased risk for developing alcohol-related cirrhosis and hepatocellular carcinoma (HCC). Recently, rs72613567:TA in hydrox... Read More about Genetic variation in HSD17B13 reduces the risk of developing cirrhosis and hepatocellular carcinoma in alcohol misusers.

Hyaluronate Carboxymethylcellulose-Based Bioresorbable Membrane Facilitates a Two-Stage Pancreaticoduodenectomy: Unnecessarily Necessary? (2019)
Journal Article
Sanyal, S., & Lobo, D. (2020). Hyaluronate Carboxymethylcellulose-Based Bioresorbable Membrane Facilitates a Two-Stage Pancreaticoduodenectomy: Unnecessarily Necessary?. World Journal of Surgery, 44, 910–911. https://doi.org/10.1007/s00268-019-05319-x

Recommendations from the ERAS® Society for standards for the development of enhanced recovery after surgery guidelines (2019)
Journal Article
Brindle, M., Nelson, G., Lobo, D. N., Ljungqvist, O., & Gustafsson, U. O. (2020). Recommendations from the ERAS® Society for standards for the development of enhanced recovery after surgery guidelines. BJS Open, 4(1), 157-163. https://doi.org/10.1002/bjs5.50238

Background
ERAS® Society guidelines are holistic, multidisciplinary tools designed to improve outcomes after surgery. The enhanced recovery after surgery (ERAS) approach was initially developed for colorectal surgery and has been implemented success... Read More about Recommendations from the ERAS® Society for standards for the development of enhanced recovery after surgery guidelines.

Publication governance in Clinical Nutrition (2019)
Journal Article
Lobo, D. N., & Deutz, N. (2020). Publication governance in Clinical Nutrition. Clinical Nutrition, 39(1), 1-4. https://doi.org/10.1016/j.clnu.2019.11.010