All Outputs (6)

Protein Oxidative Modifications in Neurodegenerative Diseases: From Advances in Detection and Modelling to Their Use as Disease Biomarkers (2024)
Journal Article
Anjo, S. I., He, Z., Hussain, Z., Farooq, A., McIntyre, A., Laughton, C. A., …Finelli, M. J. (2024). Protein Oxidative Modifications in Neurodegenerative Diseases: From Advances in Detection and Modelling to Their Use as Disease Biomarkers. Antioxidants, 13(6), Article 681. https://doi.org/10.3390/antiox13060681

Oxidation–reduction post-translational modifications (redox-PTMs) are chemical alterations to amino acids of proteins. Redox-PTMs participate in the regulation of protein conformation, localization and function, acting as signalling effectors that im... Read More about Protein Oxidative Modifications in Neurodegenerative Diseases: From Advances in Detection and Modelling to Their Use as Disease Biomarkers.

NANOG controls testicular germ cell tumour stemness through regulation of MIR9-2 (2024)
Journal Article
Cardenas, R. P., Zyoud, A., McIntyre, A., Alberio, R., Mongan, N. P., & Allegrucci, C. (2024). NANOG controls testicular germ cell tumour stemness through regulation of MIR9-2. Stem Cell Research and Therapy, 15(1), Article 128. https://doi.org/10.1186/s13287-024-03724-1

Background Testicular germ cell tumours (TGCTs) represent a clinical challenge; they are most prevalent in young individuals and are triggered by molecular mechanisms that are not fully understood. The origin of TGCTs can be traced back to primordia... Read More about NANOG controls testicular germ cell tumour stemness through regulation of MIR9-2.

Drug-resilient cancer cell phenotype is acquired via polyploidization associated with early stress response coupled to HIF-2α transcriptional regulation (2024)
Journal Article
Carroll, C., Manaprasertsak, A., Boffelli Castro, A., van den Bos, H., Spierings, D. C., Wardenaar, R., …Hammarlund, E. U. (2024). Drug-resilient cancer cell phenotype is acquired via polyploidization associated with early stress response coupled to HIF-2α transcriptional regulation. Cancer Research Communications, 4(3), 691-705. https://doi.org/10.1158/2767-9764.crc-23-0396

Therapeutic resistance and recurrence remain core challenges in cancer therapy. How therapy resistance arises is currently not fully understood with tumors surviving via multiple alternative routes. Here, we demonstrate that a subset of cancer cells... Read More about Drug-resilient cancer cell phenotype is acquired via polyploidization associated with early stress response coupled to HIF-2α transcriptional regulation.

Spatial functional mapping of hypoxia inducible factor heterodimerisation and immune checkpoint regulators in clear cell renal cell carcinoma (2024)
Journal Article
Safrygina, E., Applebee, C., McIntyre, A., Padget, J., & Larijani, B. (2024). Spatial functional mapping of hypoxia inducible factor heterodimerisation and immune checkpoint regulators in clear cell renal cell carcinoma. BJC Reports, 2, Article 10. https://doi.org/10.1038/s44276-023-00033-7

Background: Clear cell renal cell carcinoma (ccRCC) is a highly malignant subtype of kidney cancer. Ninety percent of ccRCC have inactivating mutations of VHL that stabilise transcription factors, HIF1α and HIF2α, only stabilised in hypoxia. The vari... Read More about Spatial functional mapping of hypoxia inducible factor heterodimerisation and immune checkpoint regulators in clear cell renal cell carcinoma.

Classification of cancer cells at the sub-cellular level by phonon microscopy using deep learning (2023)
Journal Article
Pérez-Cota, F., Martínez-Arellano, G., La Cavera III, S., Hardiman, W., Thornton, L., Fuentes-Domínguez, R., …Clark, M. (2023). Classification of cancer cells at the sub-cellular level by phonon microscopy using deep learning. Scientific Reports, 13, Article 16228. https://doi.org/10.1038/s41598-023-42793-9

There is a consensus about the strong correlation between the elasticity of cells and tissue and their normal, dysplastic, and cancerous states. However, developments in cell mechanics have not seen significant progress in clinical applications. In t... Read More about Classification of cancer cells at the sub-cellular level by phonon microscopy using deep learning.

Endothelial Cell RNA-Seq Data: Differential Expression and Functional Enrichment Analyses to Study Phenotypic Switching (2022)
Book Chapter
Pinel, G. D., Horder, J. L., King, J. R., McIntyre, A., Mongan, N. P., López, G. G., & Benest, A. V. (2022). Endothelial Cell RNA-Seq Data: Differential Expression and Functional Enrichment Analyses to Study Phenotypic Switching. In A. V. Benest (Ed.), Angiogenesis: Methods and Protocol (369-426). Springer. https://doi.org/10.1007/978-1-0716-2059-5_29

RNA-seq is a common approach used to explore gene expression data between experimental conditions or cell types and ultimately leads to information that can shed light on the biological processes involved and inform further hypotheses. While the prot... Read More about Endothelial Cell RNA-Seq Data: Differential Expression and Functional Enrichment Analyses to Study Phenotypic Switching.