All Outputs (4)

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant (2008)
Journal Article
Kuballa, P., Huett, A., Rioux, J. D., Daly, M. J., & Xavier, R. J. (2008). Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS ONE, 3(10), Article e3391. https://doi.org/10.1371/journal.pone.0003391

The genetic risk factors predisposing individuals to the development of inflammatory bowel disease are beginning to be deciphered by genome-wide association studies. Surprisingly, these new data point towards a critical role of autophagy in the patho... Read More about Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease (2008)
Journal Article
McCarroll, S. A., Huett, A., Kuballa, P., Chilewski, S. D., Landry, A., Goyette, P., …Xavier, R. J. (2008). Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nature Genetics, 40(9), 1107-1112. https://doi.org/10.1038/ng.215

Following recent success in genome-wide association studies, a critical focus of human genetics is to understand how genetic variation at implicated loci influences cellular and disease processes. Crohn's disease (CD) is associated with SNPs around I... Read More about Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.

Neither Hide Nor Hair: The Difficulty of Identifying Useful Disease Biomarkers (2008)
Journal Article
Huett, A., & Xavier, R. J. (2008). Neither Hide Nor Hair: The Difficulty of Identifying Useful Disease Biomarkers. Gastroenterology, 134(7), 2164-2168. https://doi.org/10.1053/j.gastro.2008.04.013

Robert Koch was the first to propose a series of definitive tests to determine the agents of infectious disease. Koch's postulates, first published in 1890, were subsequently updated for the molecular era in 1988 by Stanley Falkow1 and continue to fo... Read More about Neither Hide Nor Hair: The Difficulty of Identifying Useful Disease Biomarkers.

Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis (2008)
Journal Article
Xavier, R. J., Huett, A., & Rioux, J. D. (2008). Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis. Gut, 57(6), 717-720. https://doi.org/10.1136/gut.2007.134254

Crohns disease (CD) is a complex polygenic trait whereby multiple genetic and non-genetic risk factors contribute to disease susceptibility. Association testing is a statistical approach commonly used for identifying genetic risk factors for complex/... Read More about Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis.