Skip to main content

Research Repository

See what's under the surface

The multifunctional solute carrier 3A2 (SLC3A2) confers a poor prognosis in the highly proliferative breast cancer subtypes

El Ansari, Rokaya; Craze, Madeleine L.; Diez-Rodriguez, Maria; Nolan, Christopher C.; Ellis, Ian O.; Rakha, Emad A.; Green, Andrew R.

Authors

Rokaya El Ansari

Madeleine L. Craze Madeleine.Craze@nottingham.ac.uk

Maria Diez-Rodriguez

Christopher C. Nolan chris.nolan@nottingham.ac.uk

Emad A. Rakha

Andrew R. Green andrew.green@nottingham.ac.uk



Abstract

Background: Breast cancer (BC) is a heterogeneous disease characterised by variant biology, metabolic activity and patient outcome. This study aimed to evaluate the biological and prognostic value of the membrane solute carrier, SLC3A2 in BC with emphasis on the intrinsic molecular subtypes.

Methods: SLC3A2 was assessed at the genomic level, using METABRIC data (n=1,980), and proteomic level, using immunohistochemistry on TMA sections constructed from a large well-characterised primary BC cohort (n=2,500). SLC3A2 expression was correlated with clinicopathological parameters, molecular subtypes, and patient outcome.

Results: SLC3A2 mRNA and protein expression were strongly correlated with higher tumour grade and poor Nottingham prognostic index (NPI). High expression of SLC3A2 was observed in triple negative (TN), HER2+, and ER+ high proliferation subtypes. SLC3A2 mRNA and protein expression were significantly associated with the expression of c-MYC in all BC subtypes (p

Journal Article Type Article
Publication Date 2018-04
Journal British Journal of Cancer
Print ISSN 0007-0920
Electronic ISSN 1532-1827
Publisher Cancer Research UK
Peer Reviewed Peer Reviewed
Volume 118
Issue 8
Pages 1115-1122
APA6 Citation El Ansari, R., Craze, M. L., Diez-Rodriguez, M., Nolan, C. C., Ellis, I. O., Rakha, E. A., & Green, A. R. (2018). The multifunctional solute carrier 3A2 (SLC3A2) confers a poor prognosis in the highly proliferative breast cancer subtypes. British Journal of Cancer, 118(8), 1115-1122. https://doi.org/10.1038/s41416-018-0038-5
DOI https://doi.org/10.1038/s41416-018-0038-5
Keywords SLC3A2; Breast cancer; Prognosis
Publisher URL https://www.nature.com/articles/s41416-018-0038-5
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

Files

The multifunctional solute carrier.pdf (3.1 Mb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf


The multifunctional solute carrier 3A2 (SLC3A2) confers a poor prognosis in the highly proliferative br (514 Kb)
PDF







You might also like



Downloadable Citations