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Meningeal carcinomatosis and spinal cord infiltration caused by a locally invasive pulmonary adenocarcinoma in a cat

Posporis, Christoforos; Grau-Roma, Llorenc; Travetti, Olga; Oliveira, Maria; Polledo, Laura; Wessmann, Annette

Authors

Christoforos Posporis

Llorenc Grau-Roma

Olga Travetti

Maria Oliveira

Laura Polledo

Annette Wessmann



Abstract

A 12-year-old domestic shorthair cat was presented with acute non-painful hindlimb proprioceptive ataxia localising to T3–L3 spinal cord segments. MRI revealed paravertebral muscular hyperintensity on T2-weighted images at the level of T7–T8 vertebrae. The cat improved on conservative management but deteriorated 3 months later. Repeated MRI showed meningeal enhancement at the same level and hyperintensity of the paravertebral musculature extending to the right thoracic wall and pleural space on short tau inversion recovery images. Thoracic CT showed mineralised lesions of the right lung, restricted pleural effusion and expansile bone lesions affecting multiple ribs. The cat had been treated for pyothorax 5 years earlier but manifested no current respiratory signs. Cerebrospinal fluid (CSF) examination showed lymphocytic pleocytosis but no neoplastic cells. Biopsy of the affected muscles and cytology of the lung and pleural lesions suggested a malignant epithelial cell tumour. Post-mortem examination confirmed a pulmonary adenocarcinoma locally infiltrating the thoracic wall, T7–T8 vertebrae and the spinal cord white matter. Meningeal carcinomatosis was detected with neoplastic cells invading the ventral median fissure of the spinal cord. No metastases were observed in other organs, indicating that neoplastic cells reached the spinal cord by direct extension.

Citation

Posporis, C., Grau-Roma, L., Travetti, O., Oliveira, M., Polledo, L., & Wessmann, A. (2017). Meningeal carcinomatosis and spinal cord infiltration caused by a locally invasive pulmonary adenocarcinoma in a cat. Journal of Feline Medicine and Surgery Open Reports, 3(2), https://doi.org/10.1177/2055116917742812

Journal Article Type Article
Acceptance Date Oct 16, 2017
Online Publication Date Nov 23, 2017
Publication Date Jul 1, 2017
Deposit Date Dec 12, 2017
Publicly Available Date Mar 30, 2024
Journal Journal of Feline Medicine and Surgery Open Reports
Electronic ISSN 2055-1169
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 3
Issue 2
DOI https://doi.org/10.1177/2055116917742812
Public URL https://nottingham-repository.worktribe.com/output/869816
Publisher URL https://doi.org/10.1177/2055116917742812

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