Skip to main content

Research Repository

See what's under the surface

Advanced Search

Loss of MED23 leads to poor prognosis in invasive breast cancer

Aliyeva, T.A.; Joseph, C.; Provenzano, E.; Russell, R.; Caldas, C.; Sonbul, S.; Nolan, C.; Green, A.R.; Rakha, E.A; Ellis, IO.; Mukherjee, A.

Authors

T.A. Aliyeva

C. Joseph

E. Provenzano

R. Russell

C. Caldas

S. Sonbul

C. Nolan

A.R. Green

E.A Rakha

IO. Ellis

A. Mukherjee abhik.mukherjee1@nottingham.ac.uk



Abstract

Purpose of the study: The molecular mechanism of lymphovascular invasion (LVI) which determines the early metastatic phenotype in breast cancer is still not fully understood. Lead from the METABRIC study revealed that MED23 correlated with negative LVI status (p=0.00005). Hence MED23 expression was studied at the protein level for correlations with LVI and other clinical-pathological parameters.
Methods: The METABRIC BC cohort (n=1980) was evaluated for MED23 mRNA expression and prognostic impact externally validated using the online bc-GenExminer 4.0. Correlation between MED23 protein expression with clinicopathological parameters, patient outcome and other biomarkers were explored (Nottingham Tenovus series; n=1255) using immunohistochemistry (IHC).
Results: High MED23 mRNA expression was negatively associated with tumour stage and was differentially expressed in good prognosis integrative clusters 7 and 8 (p

Publication Date Jun 20, 2017
Peer Reviewed Peer Reviewed
Article Number O24
APA6 Citation Aliyeva, T., Joseph, C., Provenzano, E., Russell, R., Caldas, C., Sonbul, S., …Mukherjee, A. (2017). Loss of MED23 leads to poor prognosis in invasive breast cancer
Publisher URL https://www.path.org.uk/wp-content/uploads/2017/06/BP2017-PLENARY-ORAL-ABSTRACTS-05.06.17.pdf
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

Files

med23abstract.pdf (105 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





You might also like



Downloadable Citations

;