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Dependency and health utilities in stroke: data to inform cost-effectiveness analyses

Ali, Myzoon; MacIsaac, Rachael; Quinn, Terence J.; Bath, Philip M.W.; Veenstra, David L.; Xu, Yaping; Brady, Marian C.; Patel, Anita; Lees, Kennedy R.

Authors

Myzoon Ali

Rachael MacIsaac

Terence J. Quinn

Philip M.W. Bath

David L. Veenstra

Yaping Xu

Marian C. Brady

Anita Patel

Kennedy R. Lees



Abstract

Introduction: Health utilities (HU) assign preference weights to specific health states and are required for costeffectiveness analyses. Existing HU for stroke inadequately reflect the spectrum of post-stroke disability. Using international stroke trial data, we calculated HU stratified by disability to improve precision in future cost-effectiveness analyses.
Materials and methods: We used European Quality of Life Score (EQ-5D-3L) data from the Virtual International Stroke Trials Archive (VISTA) to calculate HU, stratified by modified Rankin Scale scores (mRS) at 3 months. We applied published value sets to generate HU, and validated these using ordinary least squares regression, adjusting for age and baseline National Institutes of Health Stroke Scale (NIHSS) scores.
Results: We included 3858 patients with acute ischemic stroke in our analysis (mean age: 67.5+-12.5, baseline NIHSS: 12+-5). We derived HU using value sets from 13 countries and observed significant international variation in HU distributions (Wilcoxon signed-rank test p

Citation

Ali, M., MacIsaac, R., Quinn, T. J., Bath, P. M., Veenstra, D. L., Xu, Y., …Lees, K. R. (2017). Dependency and health utilities in stroke: data to inform cost-effectiveness analyses. European Stroke Journal, 2(1), https://doi.org/10.1177/2396987316683780

Journal Article Type Article
Acceptance Date Nov 18, 2016
Online Publication Date Dec 7, 2016
Publication Date Mar 1, 2017
Deposit Date Aug 16, 2017
Publicly Available Date Mar 28, 2024
Journal European Stroke Journal
Electronic ISSN 2396-9873
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 2
Issue 1
DOI https://doi.org/10.1177/2396987316683780
Keywords Stroke, trial, health utility, EQ-5D, cost effectiveness, modified Rankin Scale, quality of life
Public URL https://nottingham-repository.worktribe.com/output/842377
Publisher URL http://journals.sagepub.com/doi/10.1177/2396987316683780