Dependency and health utilities in stroke: data to inform cost-effectiveness analyses
Ali, Myzoon; MacIsaac, Rachael; Quinn, Terence J.; Bath, Philip M.W.; Veenstra, David L.; Xu, Yaping; Brady, Marian C.; Patel, Anita; Lees, Kennedy R.
Terence J. Quinn
Philip M.W. Bath
David L. Veenstra
Marian C. Brady
Kennedy R. Lees
Introduction: Health utilities (HU) assign preference weights to specific health states and are required for costeffectiveness analyses. Existing HU for stroke inadequately reflect the spectrum of post-stroke disability. Using international stroke trial data, we calculated HU stratified by disability to improve precision in future cost-effectiveness analyses.
Materials and methods: We used European Quality of Life Score (EQ-5D-3L) data from the Virtual International Stroke Trials Archive (VISTA) to calculate HU, stratified by modified Rankin Scale scores (mRS) at 3 months. We applied published value sets to generate HU, and validated these using ordinary least squares regression, adjusting for age and baseline National Institutes of Health Stroke Scale (NIHSS) scores.
Results: We included 3858 patients with acute ischemic stroke in our analysis (mean age: 67.5+-12.5, baseline NIHSS: 12+-5). We derived HU using value sets from 13 countries and observed significant international variation in HU distributions (Wilcoxon signed-rank test p
|Journal Article Type||Article|
|Publication Date||Mar 1, 2017|
|Journal||European Stroke Journal|
|Publisher||SAGE Publications (UK and US)|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Ali, M., MacIsaac, R., Quinn, T. J., Bath, P. M., Veenstra, D. L., Xu, Y., …Lees, K. R. (2017). Dependency and health utilities in stroke: data to inform cost-effectiveness analyses. European Stroke Journal, 2(1), doi:10.1177/2396987316683780|
|Keywords||Stroke, trial, health utility, EQ-5D, cost effectiveness, modified Rankin Scale, quality of life|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf|
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