Myzoon Ali
Dependency and health utilities in stroke: data to inform cost-effectiveness analyses
Ali, Myzoon; MacIsaac, Rachael; Quinn, Terence J.; Bath, Philip M.W.; Veenstra, David L.; Xu, Yaping; Brady, Marian C.; Patel, Anita; Lees, Kennedy R.
Authors
Rachael MacIsaac
Terence J. Quinn
Philip M.W. Bath
David L. Veenstra
Yaping Xu
Marian C. Brady
Anita Patel
Kennedy R. Lees
Abstract
Introduction: Health utilities (HU) assign preference weights to specific health states and are required for costeffectiveness analyses. Existing HU for stroke inadequately reflect the spectrum of post-stroke disability. Using international stroke trial data, we calculated HU stratified by disability to improve precision in future cost-effectiveness analyses.
Materials and methods: We used European Quality of Life Score (EQ-5D-3L) data from the Virtual International Stroke Trials Archive (VISTA) to calculate HU, stratified by modified Rankin Scale scores (mRS) at 3 months. We applied published value sets to generate HU, and validated these using ordinary least squares regression, adjusting for age and baseline National Institutes of Health Stroke Scale (NIHSS) scores.
Results: We included 3858 patients with acute ischemic stroke in our analysis (mean age: 67.5+-12.5, baseline NIHSS: 12+-5). We derived HU using value sets from 13 countries and observed significant international variation in HU distributions (Wilcoxon signed-rank test p
Citation
Ali, M., MacIsaac, R., Quinn, T. J., Bath, P. M., Veenstra, D. L., Xu, Y., …Lees, K. R. (2017). Dependency and health utilities in stroke: data to inform cost-effectiveness analyses. European Stroke Journal, 2(1), https://doi.org/10.1177/2396987316683780
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 18, 2016 |
Online Publication Date | Dec 7, 2016 |
Publication Date | Mar 1, 2017 |
Deposit Date | Aug 16, 2017 |
Publicly Available Date | Mar 28, 2024 |
Journal | European Stroke Journal |
Electronic ISSN | 2396-9873 |
Publisher | SAGE Publications |
Peer Reviewed | Peer Reviewed |
Volume | 2 |
Issue | 1 |
DOI | https://doi.org/10.1177/2396987316683780 |
Keywords | Stroke, trial, health utility, EQ-5D, cost effectiveness, modified Rankin Scale, quality of life |
Public URL | https://nottingham-repository.worktribe.com/output/842377 |
Publisher URL | http://journals.sagepub.com/doi/10.1177/2396987316683780 |
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