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Dependency and health utilities in stroke: data to inform cost-effectiveness analyses

Ali, Myzoon; MacIsaac, Rachael; Quinn, Terence J.; Bath, Philip M.W.; Veenstra, David L.; Xu, Yaping; Brady, Marian C.; Patel, Anita; Lees, Kennedy R.


Myzoon Ali

Rachael MacIsaac

Terence J. Quinn

Philip M.W. Bath

David L. Veenstra

Yaping Xu

Marian C. Brady

Anita Patel

Kennedy R. Lees


Introduction: Health utilities (HU) assign preference weights to specific health states and are required for costeffectiveness analyses. Existing HU for stroke inadequately reflect the spectrum of post-stroke disability. Using international stroke trial data, we calculated HU stratified by disability to improve precision in future cost-effectiveness analyses.
Materials and methods: We used European Quality of Life Score (EQ-5D-3L) data from the Virtual International Stroke Trials Archive (VISTA) to calculate HU, stratified by modified Rankin Scale scores (mRS) at 3 months. We applied published value sets to generate HU, and validated these using ordinary least squares regression, adjusting for age and baseline National Institutes of Health Stroke Scale (NIHSS) scores.
Results: We included 3858 patients with acute ischemic stroke in our analysis (mean age: 67.5+-12.5, baseline NIHSS: 12+-5). We derived HU using value sets from 13 countries and observed significant international variation in HU distributions (Wilcoxon signed-rank test p

Journal Article Type Article
Publication Date Mar 1, 2017
Journal European Stroke Journal
Electronic ISSN 2396-9873
Publisher SAGE Publications (UK and US)
Peer Reviewed Peer Reviewed
Volume 2
Issue 1
APA6 Citation Ali, M., MacIsaac, R., Quinn, T. J., Bath, P. M., Veenstra, D. L., Xu, Y., …Lees, K. R. (2017). Dependency and health utilities in stroke: data to inform cost-effectiveness analyses. European Stroke Journal, 2(1), doi:10.1177/2396987316683780
Keywords Stroke, trial, health utility, EQ-5D, cost effectiveness, modified Rankin Scale, quality of life
Publisher URL
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf