CHAO CHEN Chao.Chen@nottingham.ac.uk
Transitional Assistant Professor
The role of anti-aquaporin 4 antibody in the conversion of acute brainstem syndrome to neuromyelitis optica
Cheng, Chen; Jiang, Ying; Lu, Xiaodong; Gu, Fu; Kang, Zhuang; Dai, Yongqiang; Lu, Zhengqi; Hu, Xueqiang
Authors
Ying Jiang
Xiaodong Lu
Fu Gu
Zhuang Kang
Yongqiang Dai
Zhengqi Lu
Xueqiang Hu
Abstract
Background: Acute brainstem syndrome (ABS) may herald multiple sclerosis (MS), neuromyelitis optica (NMO), or occur as an isolated syndrome. The aquaporin 4 (AQP4)-specific serum autoantibody, NMO-IgG, is a biomarker for NMO. However, the role of anti-AQP4 antibody in the conversion of ABS to NMO is unclear.
Methods: Thirty-one patients with first-event ABS were divided into two groups according to the presence of anti-AQP4 antibodies, their clinical features and outcomes were retrospectively analyzed.
Results: Fourteen of 31 patients (45.16 %) were seropositive for NMO-IgG. The 71.43 % of anti-AQP4 (+) ABS patients converted to NMO, while only 11.76 % of anti-AQP4 (-) ABS patients progressed to NMO. Anti-AQP4 (+) ABS patients demonstrated a higher IgG index (0.68 ± 0.43 vs 0.42 ± 0.13, p
Citation
Cheng, C., Jiang, Y., Lu, X., Gu, F., Kang, Z., Dai, Y., …Hu, X. (in press). The role of anti-aquaporin 4 antibody in the conversion of acute brainstem syndrome to neuromyelitis optica. BMC Neurology, 16(1), https://doi.org/10.1186/s12883-016-0721-1
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 16, 2016 |
Online Publication Date | Oct 21, 2016 |
Deposit Date | Oct 18, 2017 |
Publicly Available Date | Oct 18, 2017 |
Journal | BMC Neurology |
Electronic ISSN | 1471-2377 |
Publisher | Springer Verlag |
Peer Reviewed | Peer Reviewed |
Volume | 16 |
Issue | 1 |
DOI | https://doi.org/10.1186/s12883-016-0721-1 |
Keywords | Acute brainstem syndrome; Anti-aquaporin 4 antibody; Neuromyelitis optica; Magnetic resonance imaging |
Public URL | https://nottingham-repository.worktribe.com/output/822188 |
Publisher URL | https://doi.org/10.1186/s12883-016-0721-1 |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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