Longitudinal course of behavioural and psychological symptoms of dementia: systematic review

van der Linde, Rianne M.; Dening, Tom; Stephan, Blossom C.M.; Prina, A. Matthew; Evans, Elizabeth; Brayne, Carol

Abstract

Background
More information about the pattern of Behavioural and Psychological Symptoms of Dementia (BPSD) in the course of dementia is needed to inform patients and clinicians and to design future interventions.

Aims
To determine the persistence and incidence of BPSD and their relation to cognitive function, in individuals with dementia or in cohorts investigating dementia onset.

Methods
Systematic literature review of baseline prevalence, persistence and incidence of 11 BPSD. The review was conducted according to established (PRISMA) guidelines with the exception that we could not exclude the possibilities of bias in the studies examined.

Results
59 studies were included. There was considerable heterogeneity in study objectives and methods. Hyperactivity and apathy showed high persistence and incidence; depression and anxiety low or moderate persistence and moderate incidence; and psychotic symptoms low persistence with moderate or low incidence.

Conclusions
Despite heterogeneity across studies in terms of setting, focus and length of follow-up, there are clinically relevant differences in the longitudinal courses of different BPSD. Apathy was the only single BPSD with high baseline prevalence, persistence and incidence during the course of dementia.

Citation

van der Linde, R. M., Dening, T., Stephan, B. C., Prina, A. M., Evans, E., & Brayne, C. (2016). Longitudinal course of behavioural and psychological symptoms of dementia: systematic review. British Journal of Psychiatry, 209(5), 366-377. https://doi.org/10.1192/bjp.bp.114.148403

• Journal Article Type: Article
• Acceptance Date: Feb 27, 2016
• Online Publication Date: Jan 2, 2018
• Publication Date: 2016-11
• Deposit Date: Jul 10, 2016
• Publicly Available Date: Nov 30, 2016
• Journal: British Journal of Psychiatry
• Print ISSN: 0007-1250
• Electronic ISSN: 1472-1465
• Publisher: Cambridge University Press
• Peer Reviewed: Peer Reviewed
• Volume: 209
• Issue: 5
• Pages: 366-377
• DOI: https://doi.org/10.1192/bjp.bp.114.148403
• Keywords: Psychiatry and Mental health
• Public URL: https://nottingham-repository.worktribe.com/output/820177
• Publisher URL: http://bjp.rcpsych.org/content/209/5/366
• Contract Date: Jul 10, 2016