Karla L. Miller
Multimodal population brain imaging in the UK Biobank prospective epidemiological study
Miller, Karla L.; Alfaro-Almagro, Fidel; Bangerter, Neal K.; Thomas, David L.; Yacoub, Essa; Xu, Junqian; Bartsch, Andreas J.; Jbabdi, Saad; Sotiropoulos, Stamatios N.; Andersson, Jesper L.R.; Griffanti, Ludovica; Douaud, Gwena�lle; Okell, Thomas W.; Weale, Peter; Dragonu, Iulius; Garratt, Steve; Hudson, Sarah; Collins, Rory; Jenkinson, Mark; Matthews, Paul M.; Smith, Stephen M.
Authors
Fidel Alfaro-Almagro
Neal K. Bangerter
David L. Thomas
Essa Yacoub
Junqian Xu
Andreas J. Bartsch
Saad Jbabdi
STAMATIOS SOTIROPOULOS STAMATIOS.SOTIROPOULOS@NOTTINGHAM.AC.UK
Professor of Computational Neuroimaging
Jesper L.R. Andersson
Ludovica Griffanti
Gwena�lle Douaud
Thomas W. Okell
Peter Weale
Iulius Dragonu
Steve Garratt
Sarah Hudson
Rory Collins
Mark Jenkinson
Paul M. Matthews
Stephen M. Smith
Abstract
Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, with health outcomes being tracked over the coming decades. The brain imaging includes structural, diffusion and functional modalities. Along with body and cardiac imaging, genetics, lifestyle measures, biological phenotyping and health records, this imaging is expected to enable discovery of imaging markers of a broad range of diseases at their earliest stages, as well as provide unique insight into disease mechanisms. We describe UK Biobank brain imaging and present results derived from the first 5,000 participants' data release. Although this covers just 5% of the ultimate cohort, it has already yielded a rich range of associations between brain imaging and other measures collected by UK Biobank.
Citation
Miller, K. L., Alfaro-Almagro, F., Bangerter, N. K., Thomas, D. L., Yacoub, E., Xu, J., …Smith, S. M. (2016). Multimodal population brain imaging in the UK Biobank prospective epidemiological study. Nature Neuroscience, 19(11), https://doi.org/10.1038/nn.4393
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 25, 2016 |
Publication Date | Sep 19, 2016 |
Deposit Date | Apr 5, 2018 |
Publicly Available Date | Apr 5, 2018 |
Journal | Nature Neuroscience |
Print ISSN | 1097-6256 |
Electronic ISSN | 1546-1726 |
Publisher | Nature Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 19 |
Issue | 11 |
DOI | https://doi.org/10.1038/nn.4393 |
Keywords | Cognitive ageing; Neurological disorders; Predictive markers |
Public URL | https://nottingham-repository.worktribe.com/output/817017 |
Publisher URL | https://www.nature.com/articles/nn.4393 |
Contract Date | Apr 5, 2018 |
Files
NatureNeuroscience_Biobank_EPMC.pdf
(19.7 Mb)
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