Invasiveness of pharmacokinetic studies in children: a systematic review

Altamimi, Mohammed; Choonara, Imti; Sammons, Helen

Abstract

Objectives: To explore whether pharmacokinetic (PK) studies in paediatric patients are becoming less invasive. This will be evaluated by analysing the number of samples and volume of blood collected for each study within four different decades.
Methods: A systematic literature review was performed to identify PK papers describing number of samples and volume of blood collected in studies of children aged 0–18 years. The following databases were searched: MEDLINE (1946 to December 2015), EMBASE (1974 to December 2015), International Pharmaceutical Abstracts (1970 to December 2015), CINAHL and Cochrane Library.
Results: A total of 549 studies were identified between 1974 and 2015. There were 52 studies between 1976 and 1985, 105 between 1986 and 1995, 201 between 1996 and 2005 and 191 between 2006 and 2015. The number of blood samples collected per participant increased between the first two decades (p=0.013), but there was a decrease in the number of samples in the subsequent two decades (p=0.044 and p

Citation

Altamimi, M., Choonara, I., & Sammons, H. (2016). Invasiveness of pharmacokinetic studies in children: a systematic review. BMJ Open, 6, Article e010484

• Journal Article Type: Article
• Acceptance Date: Jun 14, 2016
• Publication Date: Jul 18, 2016
• Deposit Date: Sep 27, 2016
• Publicly Available Date: Sep 27, 2016
• Journal: BMJ Open
• Electronic ISSN: 2044-6055
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Article Number: e010484
• Public URL: https://nottingham-repository.worktribe.com/output/800487
• Publisher URL: http://bmjopen.bmj.com/content/6/7/e010484.abstract
• Contract Date: Sep 27, 2016