Vibrational Biospectroscopy: An Alternative Approach to Endometrial Cancer Diagnosis and Screening

Schiemer, Roberta; Furniss, David; Phang, Sendy; Seddon, Angela B.; Atiomo, William; Gajjar, Ketankumar B.

Abstract

Endometrial cancer (EC) is the sixth most common cancer and the fourth leading cause of death among women worldwide. Early detection and treatment are associated with a favourable prognosis and reduction in mortality. Unlike other common cancers, however, screening strategies lack the required sensitivity, specificity and accuracy to be successfully implemented in clinical practice and current diagnostic approaches are invasive, costly and time consuming. Such limitations highlight the unmet need to develop diagnostic and screening alternatives for EC, which should be accurate, rapid, minimally invasive and cost-effective. Vibrational spectroscopic techniques, Mid-Infrared Absorption Spectroscopy and Raman, exploit the atomic vibrational absorption induced by interaction of light and a biological sample, to generate a unique spectral response: a “biochemical fingerprint”. These are non-destructive techniques and, combined with multivariate statistical analysis, have been shown over the last decade to provide discrimination between cancerous and healthy samples, demonstrating a promising role in both cancer screening and diagnosis. The aim of this review is to collate available evidence, in order to provide insight into the present status of the application of vibrational biospectroscopy in endometrial cancer diagnosis and screening, and to assess future prospects.

Citation

Schiemer, R., Furniss, D., Phang, S., Seddon, A. B., Atiomo, W., & Gajjar, K. B. (2022). Vibrational Biospectroscopy: An Alternative Approach to Endometrial Cancer Diagnosis and Screening. International Journal of Molecular Sciences, 23(9), Article 4859. https://doi.org/10.3390/ijms23094859

• Journal Article Type: Article
• Acceptance Date: Apr 26, 2022
• Online Publication Date: Apr 27, 2022
• Publication Date: May 1, 2022
• Deposit Date: Apr 29, 2022
• Publicly Available Date: May 5, 2022
• Journal: International Journal of Molecular Sciences
• Print ISSN: 1661-6596
• Electronic ISSN: 1422-0067
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 23
• Issue: 9
• Article Number: 4859
• DOI: https://doi.org/10.3390/ijms23094859
• Keywords: Inorganic Chemistry; Organic Chemistry; Physical and Theoretical Chemistry; Computer Science Applications; Spectroscopy; Molecular Biology; General Medicine; Catalysis
• Public URL: https://nottingham-repository.worktribe.com/output/7839815
• Publisher URL: https://www.mdpi.com/1422-0067/23/9/4859