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The pattern of learned visual improvements in adult amblyopia

Astle, Andrew T.; Webb, Ben S.; McGraw, Paul V.

Authors

Andrew T. Astle

Ben S. Webb

Paul V. McGraw

Abstract

Purpose. Although amblyopia is diagnosed in terms of a monocular letter acuity loss, individuals typically present with deficits on a wide range of spatial tasks. Many of these deficits can be collapsed along two basic visual dimensions (visual acuity and contrast sensitivity) that together account for most of the variability in performance of the amblyopic visual system. In this study, this space was exploited, to target the main deficits and fully characterize the pattern of learned visual improvements in adult amblyopic subjects.

Methods. Twenty-six amblyopic subjects (mean age, 39 ±12 years) were trained on one of four tasks, categorized as either visual acuity (letter or grating acuity) or contrast sensitivity (letter or grating contrast) tasks. Performance was measured on all tasks before and after training, to quantify learning along each dimension and generalization to the other dimension. Performance in 35 visually normal subjects (mean, age 24 ± 5 years) was used to establish normal variation in visual performance along each dimension, against which the learned improvements in amblyopic subjects was compared.

Results. Training on the contrast sensitivity tasks produced substantial within-task learning and generalization to measures of visual acuity. The learned improvements in performance after training on the letter acuity task were also substantial, but did not generalize to contrast sensitivity.

Conclusions. Mapping the pattern of learning onto the known deficit space for amblyopia enabled the identification of tasks and stimulus configurations that optimized learning, guiding further development of learning-based interventions in this clinical group.

Journal Article Type Article
Publication Date Sep 13, 2011
Journal Investigative Ophthalmology & Visual Science
Print ISSN 0146-0404
Electronic ISSN 0146-0404
Publisher Association for Research in Vision and Ophthalmology
Peer Reviewed Peer Reviewed
Volume 52
Issue 10
Institution Citation Astle, A. T., Webb, B. S., & McGraw, P. V. (2011). The pattern of learned visual improvements in adult amblyopia. Investigative Ophthalmology & Visual Science, 52(10), doi:10.1167/iovs.11-7584
DOI https://doi.org/10.1167/iovs.11-7584
Keywords Eye Movements, Strabismus, Amblyopia, Neuro-Ophthalmology
Publisher URL http://www.iovs.org/content/52/10/7195.short
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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