The convergence and divergence of episodic and semantic functions across lateral parietal cortex

Humphreys, Gina F.; Jung, JeYoung; Lambon Ralph, Matthew A

Abstract

Decades of research have highlighted the importance of lateral parietal cortex (LPC) across a myriad of cognitive domains. Yet, the underlying function of LPC remains unclear. Two domains that have emphasized LPC involvement are semantic memory and episodic memory retrieval. From each domain, sophisticated functional models have been proposed, as well as the more domain-general assumption that LPC is engaged by any form of internally directed cognition (episodic/semantic retrieval being examples). Here we used a combination of functional magnetic resonance imaging, functional connectivity, and diffusion tensor imaging white-matter connectivity to show that (i) ventral LPC (angular gyrus [AG]) was positively engaged during episodic retrieval but disengaged during semantic memory retrieval and (ii) activity negatively varied with task difficulty in the semantic task whereas episodic activation was independent of difficulty. In contrast, dorsal LPC (intraparietal sulcus) showed domain general activation that was positively correlated with task difficulty. Finally, (iii) a dorsal-ventral and anterior-posterior gradient of functional and structural connectivity was found across the AG (e.g. mid-AG connected with episodic retrieval). We propose a unifying model in which LPC as a whole might share a common underlying neurocomputation (multimodal buffering) with variations in the emergent cognitive functions across subregions arising from differences in the underlying connectivity.

Citation

Humphreys, G. F., Jung, J., & Lambon Ralph, M. A. (2022). The convergence and divergence of episodic and semantic functions across lateral parietal cortex. Cerebral Cortex, 32(24), 5664-5681. https://doi.org/10.1093/cercor/bhac044

• Journal Article Type: Article
• Acceptance Date: Jan 22, 2022
• Online Publication Date: Feb 23, 2022
• Publication Date: Dec 15, 2022
• Deposit Date: Mar 8, 2022
• Publicly Available Date: Mar 10, 2022
• Journal: Cerebral Cortex
• Print ISSN: 1047-3211
• Electronic ISSN: 1460-2199
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 32
• Issue: 24
• Pages: 5664-5681
• DOI: https://doi.org/10.1093/cercor/bhac044
• Keywords: Cellular and Molecular Neuroscience, Cognitive Neuroscience
• Public URL: https://nottingham-repository.worktribe.com/output/5141889
• Publisher URL: https://academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhac044/6535014