Jason G. Skinner
High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments
Skinner, Jason G.; Ranta, Kaili; Whiting, Nicholas; Coffey, Aaron M.; Nikolaou, Panayiotis; Rosen, Matthew S.; Chekmenev, Eduard Y.; Morris, Peter G.; Barlow, Michael J.; Goodson, Boyd M.
Aaron M. Coffey
Matthew S. Rosen
Eduard Y. Chekmenev
PETER MORRIS firstname.lastname@example.org
Professor of Physics
Michael J. Barlow
Boyd M. Goodson
© 2020 Elsevier Inc. Spin-exchange optical pumping (SEOP) can enhance the NMR sensitivity of noble gases by up to five orders of magnitude at Tesla-strength magnetic fields. SEOP-generated hyperpolarised (HP) 129Xe is a promising contrast agent for lung imaging but an ongoing barrier to widespread clinical usage has been economical production of sufficient quantities with high 129Xe polarisation. Here, the ‘standard model’ of SEOP, which was previously used in the optimisation of continuous-flow 129Xe polarisers, is modified for validation against two Xe-rich stopped-flow SEOP datasets. We use this model to examine ways to increase HP Xe production efficiency in stopped-flow 129Xe polarisers and provide further insight into the underlying physics of Xe-rich stopped-flow SEOP at high laser fluxes.
|Journal Article Type||Article|
|Journal||Journal of Magnetic Resonance|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Skinner, J. G., Ranta, K., Whiting, N., Coffey, A. M., Nikolaou, P., Rosen, M. S., …Goodson, B. M. (2020). High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments. Journal of Magnetic Resonance, 312, https://doi.org/10.1016/j.jmr.2020.106686|
|Keywords||Nuclear and High Energy Physics; Biophysics; Biochemistry; Condensed Matter Physics|
|Additional Information||This article is maintained by: Elsevier; Article Title: High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments; Journal Title: Journal of Magnetic Resonance; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jmr.2020.106686; Content Type: article; Copyright: © 2020 Elsevier Inc. All rights reserved.|
This file is under embargo until Jan 17, 2021 due to copyright restrictions.
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