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High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments

Skinner, Jason G.; Ranta, Kaili; Whiting, Nicholas; Coffey, Aaron M.; Nikolaou, Panayiotis; Rosen, Matthew S.; Chekmenev, Eduard Y.; Morris, Peter G.; Barlow, Michael J.; Goodson, Boyd M.

Authors

Jason G. Skinner

Kaili Ranta

Nicholas Whiting

Aaron M. Coffey

Panayiotis Nikolaou

Matthew S. Rosen

Eduard Y. Chekmenev

Michael J. Barlow

Boyd M. Goodson



Abstract

© 2020 Elsevier Inc. Spin-exchange optical pumping (SEOP) can enhance the NMR sensitivity of noble gases by up to five orders of magnitude at Tesla-strength magnetic fields. SEOP-generated hyperpolarised (HP) 129Xe is a promising contrast agent for lung imaging but an ongoing barrier to widespread clinical usage has been economical production of sufficient quantities with high 129Xe polarisation. Here, the ‘standard model’ of SEOP, which was previously used in the optimisation of continuous-flow 129Xe polarisers, is modified for validation against two Xe-rich stopped-flow SEOP datasets. We use this model to examine ways to increase HP Xe production efficiency in stopped-flow 129Xe polarisers and provide further insight into the underlying physics of Xe-rich stopped-flow SEOP at high laser fluxes.

Journal Article Type Article
Publication Date 2020-03
Journal Journal of Magnetic Resonance
Print ISSN 1090-7807
Electronic ISSN 1096-0856
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 312
Article Number 106686
APA6 Citation Skinner, J. G., Ranta, K., Whiting, N., Coffey, A. M., Nikolaou, P., Rosen, M. S., …Goodson, B. M. (2020). High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments. Journal of Magnetic Resonance, 312, https://doi.org/10.1016/j.jmr.2020.106686
DOI https://doi.org/10.1016/j.jmr.2020.106686
Keywords Nuclear and High Energy Physics; Biophysics; Biochemistry; Condensed Matter Physics
Publisher URL https://www.sciencedirect.com/science/article/pii/S1090780720300045
Additional Information This article is maintained by: Elsevier; Article Title: High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments; Journal Title: Journal of Magnetic Resonance; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jmr.2020.106686; Content Type: article; Copyright: © 2020 Elsevier Inc. All rights reserved.
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