High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments

Skinner, Jason G.; Ranta, Kaili; Whiting, Nicholas; Coffey, Aaron M.; Nikolaou, Panayiotis; Rosen, Matthew S.; Chekmenev, Eduard Y.; Morris, Peter G.; Barlow, Michael J.; Goodson, Boyd M.

Abstract

© 2020 Elsevier Inc. Spin-exchange optical pumping (SEOP) can enhance the NMR sensitivity of noble gases by up to five orders of magnitude at Tesla-strength magnetic fields. SEOP-generated hyperpolarised (HP) 129Xe is a promising contrast agent for lung imaging but an ongoing barrier to widespread clinical usage has been economical production of sufficient quantities with high 129Xe polarisation. Here, the ‘standard model’ of SEOP, which was previously used in the optimisation of continuous-flow 129Xe polarisers, is modified for validation against two Xe-rich stopped-flow SEOP datasets. We use this model to examine ways to increase HP Xe production efficiency in stopped-flow 129Xe polarisers and provide further insight into the underlying physics of Xe-rich stopped-flow SEOP at high laser fluxes.

Citation

Skinner, J. G., Ranta, K., Whiting, N., Coffey, A. M., Nikolaou, P., Rosen, M. S., …Goodson, B. M. (2020). High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments. Journal of Magnetic Resonance, 312, Article 106686. https://doi.org/10.1016/j.jmr.2020.106686

• Journal Article Type: Article
• Acceptance Date: Jan 7, 2020
• Online Publication Date: Jan 16, 2020
• Publication Date: 2020-03
• Deposit Date: Mar 4, 2020
• Publicly Available Date: Jan 17, 2021
• Journal: Journal of Magnetic Resonance
• Print ISSN: 1090-7807
• Electronic ISSN: 1096-0856
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 312
• Article Number: 106686
• DOI: https://doi.org/10.1016/j.jmr.2020.106686
• Keywords: Nuclear and High Energy Physics; Biophysics; Biochemistry; Condensed Matter Physics
• Public URL: https://nottingham-repository.worktribe.com/output/4088788
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1090780720300045
• Additional Information: This article is maintained by: Elsevier; Article Title: High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments; Journal Title: Journal of Magnetic Resonance; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jmr.2020.106686; Content Type: article; Copyright: © 2020 Elsevier Inc. All rights reserved.