Quantitative photoacoustic tomography using forward and adjoint Monte Carlo models of radiance

Hochuli, Roman; Powell, Samuel; Arridge, Simon; Cox, Ben

Abstract

Forward and adjoint Monte Carlo (MC) models of radiance are proposed for use in model-based quantitative photoacoustic tomography. A two-dimensional (2-D) radiance MC model using a harmonic angular basis is introduced and validated against analytic solutions for the radiance in heterogeneous media. A gradient-based optimization scheme is then used to recover 2-D absorption and scattering coefficients distributions from simulated photoacoustic measurements. It is shown that the functional gradients, which are a challenge to compute efficiently using MC models, can be calculated directly from the coefficients of the harmonic angular basis used in the forward and adjoint models. This work establishes a framework for transport-based quantitative photoacoustic tomography that can fully exploit emerging highly parallel computing architectures.

Citation

Hochuli, R., Powell, S., Arridge, S., & Cox, B. (2016). Quantitative photoacoustic tomography using forward and adjoint Monte Carlo models of radiance. Journal of Biomedical Optics, 21(12), Article 126004. https://doi.org/10.1117/1.jbo.21.12.126004

• Journal Article Type: Article
• Acceptance Date: Nov 1, 2016
• Online Publication Date: Dec 2, 2016
• Publication Date: Dec 2, 2016
• Deposit Date: Jan 24, 2020
• Publicly Available Date: Oct 2, 2020
• Journal: Journal of Biomedical Optics
• Print ISSN: 1083-3668
• Publisher: Society of Photo-optical Instrumentation Engineers
• Peer Reviewed: Peer Reviewed
• Volume: 21
• Issue: 12
• Article Number: 126004
• DOI: https://doi.org/10.1117/1.jbo.21.12.126004
• Public URL: https://nottingham-repository.worktribe.com/output/3791714
• Publisher URL: https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-21/issue-12/126004/Quantitative-photoacoustic-tomography-using-forward-and-adjoint-Monte-Carlo-models/10.1117/1.JBO.21.12.126004.full?SSO=1