Juli� Arcau
Synthesis and biological activity of gold(I) N-heterocyclic carbene complexes with long aliphatic side chains
Arcau, Juli�; Andermark, Vincent; Rodrigues, Mafalda; Giannicchi, Ilaria; P�rez-Garcia, Llu�sa; Ott, Ingo; Rodr�guez, Laura
Authors
Vincent Andermark
Mafalda Rodrigues
Ilaria Giannicchi
Llu�sa P�rez-Garcia
Ingo Ott
Laura Rodr�guez
Contributors
LLUISA PEREZ GARCIA
Supervisor
Abstract
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Seven imidazolium salts have been synthesized from octadecylimidazole (Im18). These salts differ in the length of the alkyl chain length bound to the second nitrogen atom of the imidazolium ring [R = Me, Et, iPr, Pr, Bu, decyl (Dec), octadecyl] and were used as synthetic precursors to obtain two series of gold(I) carbene complexes (AuNHC). The first series contains one labile ligand at the second coordinative position {monocarbene, [AuCl(NHC)]}, and the second one comprises dicarbene complexes. Their biological activity has been evaluated with respect to two different cell lines, and thioredoxin reductase (TrxR) inhibition has also been evaluated for selected examples. Distinct effects have been observed for the imidazolium salts and monocarbene derivatives.
Citation
Arcau, J., Andermark, V., Rodrigues, M., Giannicchi, I., Pérez-Garcia, L., Ott, I., & Rodríguez, L. (2014). Synthesis and biological activity of gold(I) N-heterocyclic carbene complexes with long aliphatic side chains. European Journal of Inorganic Chemistry, 2014(35), 6117-6125. https://doi.org/10.1002/ejic.201402819
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 6, 2014 |
Online Publication Date | Nov 7, 2014 |
Publication Date | 2014-12 |
Deposit Date | Jan 8, 2020 |
Journal | European Journal of Inorganic Chemistry |
Print ISSN | 1434-1948 |
Electronic ISSN | 1099-0682 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 2014 |
Issue | 35 |
Pages | 6117-6125 |
DOI | https://doi.org/10.1002/ejic.201402819 |
Public URL | https://nottingham-repository.worktribe.com/output/3691514 |
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