The Role Of Glutaminase In Cancer

Masisi, Brendah; El Ansari, Rokaya; Alfarsi, Lutfi; Rakha, Emad; Green, Andrew; Craze, Madeleine

Abstract

Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised as a key metabolic change in cancer cells. As a heterogeneous disease with different morpholog- ical and molecular subtypes and response to therapy, breast cancer cells are known to rewire glutamine metabolism to support survival and proliferation. Glutaminase isoenzymes (GLS and GLS2) are key enzymes for glutamine metabolism. Interestingly, GLS and GLS2 display contrasting functions in tumourigenesis. In this review, we explore the role of glutaminase in cancer, primarily focussing on breast cancer, address the role played by oncogenes and tu- mour suppressor genes in regulating glutaminase, and discuss current therapeutic approaches in targeting glutaminase.

Citation

Masisi, B., El Ansari, R., Alfarsi, L., Rakha, E., Green, A., & Craze, M. (2020). The Role Of Glutaminase In Cancer. Histopathology, 76(4), 498-508. https://doi.org/10.1111/his.14014

• Journal Article Type: Review
• Acceptance Date: Oct 6, 2019
• Online Publication Date: Oct 9, 2019
• Publication Date: 2020-03
• Deposit Date: Oct 7, 2019
• Publicly Available Date: Oct 10, 2020
• Journal: Histopathology
• Print ISSN: 0309-0167
• Electronic ISSN: 1365-2559
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 76
• Issue: 4
• Pages: 498-508
• DOI: https://doi.org/10.1111/his.14014
• Keywords: glutaminase, glutamine, metabolism, cancer, breast cancer, subtypes
• Public URL: https://nottingham-repository.worktribe.com/output/2772873
• Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/his.14014
• Additional Information: This is the peer reviewed version of the following article: Masisi, B. K., El Ansari, R. , Alfarsi, L. , Rakha, E. A., Green, A. R. and Craze, M. L. (2019), The Role of Glutaminase in Cancer. Histopathology. Accepted Author Manuscript, which has been published in final form at doi:10.1111/his.14014. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
• Contract Date: Oct 7, 2019