Shariq Mohammed
Tumor radiogenomics in gliomas with Bayesian layered variable selection
Mohammed, Shariq; Kurtek, Sebastian; Bharath, Karthik; Rao, Arvind; Baladandayuthapani, Veerabhadran
Authors
Sebastian Kurtek
KARTHIK BHARATH Karthik.Bharath@nottingham.ac.uk
Professor of Statistics
Arvind Rao
Veerabhadran Baladandayuthapani
Abstract
We propose a statistical framework to analyze radiological magnetic resonance imaging (MRI) and genomic data to identify the underlying radiogenomic associations in lower grade gliomas (LGG). We devise a novel imaging phenotype by dividing the tumor region into concentric spherical layers that mimics the tumor evolution process. MRI data within each layer is represented by voxel–intensity-based probability density functions which capture the complete information about tumor heterogeneity. Under a Riemannian-geometric framework these densities are mapped to a vector of principal component scores which act as imaging phenotypes. Subsequently, we build Bayesian variable selection models for each layer with the imaging phenotypes as the response and the genomic markers as predictors. Our novel hierarchical prior formulation incorporates the interior-to-exterior structure of the layers, and the correlation between the genomic markers. We employ a computationally-efficient Expectation–Maximization-based strategy for estimation. Simulation studies demonstrate the superior performance of our approach compared to other approaches. With a focus on the cancer driver genes in LGG, we discuss some biologically relevant findings. Genes implicated with survival and oncogenesis are identified as being associated with the spherical layers, which could potentially serve as early-stage diagnostic markers for disease monitoring, prior to routine invasive approaches. We provide a R package that can be used to deploy our framework to identify radiogenomic associations.
Journal Article Type | Article |
---|---|
Acceptance Date | Jul 3, 2023 |
Online Publication Date | Oct 3, 2023 |
Publication Date | Dec 1, 2023 |
Deposit Date | Sep 19, 2023 |
Publicly Available Date | Sep 20, 2023 |
Journal | Medical Image Analysis |
Print ISSN | 1361-8415 |
Publisher | Elsevier BV |
Peer Reviewed | Peer Reviewed |
Volume | 90 |
Article Number | 102964 |
DOI | https://doi.org/10.1016/j.media.2023.102964 |
Keywords | Cancer driver genes, Lower grade gliomas, Magnetic resonance imaging, Radiogenomic associations, Spike-and-slab prior |
Public URL | https://nottingham-repository.worktribe.com/output/25362179 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S1361841523002244?via%3Dihub |
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Tumor radiogenomics in gliomas with Bayesian layered variable selection
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Publisher Licence URL
https://creativecommons.org/licenses/by-nc/4.0/
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