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Assessment of Circulating Anti-Müllerian Hormone in Women Using Hormonal Contraception: A Systematic Review

Amer, Saad A.K.S.; James, Cathryn; Al-Hussaini, Tarek Khalf; Mohamed, Ahmed Aboelfadle

Assessment of Circulating Anti-Müllerian Hormone in Women Using Hormonal Contraception: A Systematic Review Thumbnail


Authors

Profile image of SAAD AMER

SAAD AMER saad.amer@nottingham.ac.uk
Professor of Gynaecology and Reproductive Medicine

Cathryn James

Tarek Khalf Al-Hussaini

Ahmed Aboelfadle Mohamed



Abstract

Background: The status of ovarian reserve markers during hormonal contraception (HC) remains uncertain with conflicting literature data. The purpose of this study was to assess the impact of HC on circulating anti-Müllerian hormone (AMH) and other ovarian reserve markers.

Materials and Methods: A systematic review was conducted, including all cohort, cross-sectional, and randomized controlled studies assessing serum anti Müllerian hormone concentration in women using HC. Data sources included MEDLINE, EMBASE, DynaMed Plus, ScienceDirect, TRIP database, ClinicalTrials.gov, and the Cochrane Library from January 2000 to October 2018.

Results: A total of 366 studies were identified, of which 15 were eligible, including 3280 women, mostly using combined HC (CHC). Articles were divided according to duration of HC into short- (2–3 weeks), medium- (2–6 months), long- (>1 year), and varied-term studies. Two study designs were identified, including studies comparing AMH before and during/after CHC and studies comparing CHC users versus nonusers. Short- and medium-term studies (n = 284) reported no change in circulating AMH in women using cyclical CHC for one to six cycles. Apart from one study, all long- and varied-term studies (six studies, n = 1601) consistently showed a marked decline in AMH, antral follicle count, and ovarian volume. Three long-term studies (n = 1324) provided evidence of AMH recovery after discontinuation of HC.

Conclusion: Circulating AMH seems to remain unchanged in women using cyclical CHC for up to 6 months, but appears to markedly decline in long-term users with recovery after discontinuation.

Citation

Amer, S. A., James, C., Al-Hussaini, T. K., & Mohamed, A. A. (2019). Assessment of Circulating Anti-Müllerian Hormone in Women Using Hormonal Contraception: A Systematic Review. Journal of Women's Health, 29(1), 100-110. https://doi.org/10.1089/jwh.2019.7733

Journal Article Type Article
Acceptance Date Jun 11, 2019
Online Publication Date Jul 16, 2019
Publication Date Jul 16, 2019
Deposit Date Aug 4, 2019
Publicly Available Date Jul 17, 2020
Journal Journal of Women's Health
Print ISSN 1540-9996
Electronic ISSN 1931-843X
Publisher Mary Ann Liebert
Peer Reviewed Peer Reviewed
Volume 29
Issue 1
Pages 100-110
DOI https://doi.org/10.1089/jwh.2019.7733
Keywords Hormonal contraception, Anti-Mullerian hormone, Ovarian reserve, Antral follicle count and ovarian volume
Public URL https://nottingham-repository.worktribe.com/output/2324349
Publisher URL https://www.liebertpub.com/doi/10.1089/jwh.2019.7733
Additional Information Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/jwh.2019.7733
Contract Date Aug 4, 2019

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