The dynamic relationship between pain, depression and cognitive function in a sample of newly diagnosed arthritic adults: a cross-lagged panel model

James, Richard J. E.; Ferguson, Eamonn

Abstract

Background: Pain and depression are common in the population and co-morbid with each other. Both are also predictive of one another other, and are also associated with cognitive function; people who are in greater pain and more depressed respectively perform less well on tests of cognitive function. It has been argued that pain might cause deterioration in cognitive function, as well as better cognitive function earlier in life might be a protective factor against the emergence of disease. When looking at the dynamic relationship between these in chronic diseases, studying samples that already have advanced disease progression often confounds this relationship.

Methods: Using data from waves 1 to 3 of the English Longitudinal Study of Ageing (ELSA) (n = 516), we examined the interplay between pain, cognitive function and depression in a subsample of respondents reporting their diagnosis of arthritis at Wave 2 of the ELSA using cross-lagged panel models.

Results: The models showed that pain, cognitive function and depression at wave 1, prior to diagnosis, predict pain at wave 2, and that pain at wave 1 predicts depression at wave 2. Pain and depression at wave 2 predict cognitive function at wave 3.

Conclusions: The results indicate that better cognitive function might be protective against the emergence of pain prior to an arthritis diagnosis, but cognitive function is subsequently impaired by pain and depression. Furthermore, higher depression predicts lower cognitive function, but not vice versa. This is discussed in the context of the emerging importance of inflammation in depression.

Citation

James, R. J. E., & Ferguson, E. (2020). The dynamic relationship between pain, depression and cognitive function in a sample of newly diagnosed arthritic adults: a cross-lagged panel model. Psychological Medicine, 50(10), 1663-1671. https://doi.org/10.1017/S0033291719001673

• Journal Article Type: Article
• Acceptance Date: Jun 19, 2019
• Online Publication Date: Aug 7, 2019
• Publication Date: 2020-07
• Deposit Date: Jul 5, 2019
• Publicly Available Date: Feb 8, 2020
• Journal: Psychological Medicine
• Print ISSN: 0033-2917
• Electronic ISSN: 1469-8978
• Publisher: Cambridge University Press
• Peer Reviewed: Peer Reviewed
• Volume: 50
• Issue: 10
• Pages: 1663-1671
• DOI: https://doi.org/10.1017/S0033291719001673
• Keywords: Applied Psychology; Psychiatry and Mental health
• Public URL: https://nottingham-repository.worktribe.com/output/2272436
• Publisher URL: https://www.cambridge.org/core/journals/psychological-medicine/article/dynamic-relationship-between-pain-depression-and-cognitive-function-in-a-sample-of-newly-diagnosed-arthritic-adults-a-crosslagged-panel-model/91E3DAFE5BED339A7006550D3B8BA3CC
• Contract Date: Jul 5, 2019