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Inhibiting the ins and outs of HIV replication: cell-intrinsic antiretroviral restrictions at the plasma membrane

Foster, Toshana L.; Pickering, Suzanne; Neil, Stuart J. D.

Inhibiting the ins and outs of HIV replication: cell-intrinsic antiretroviral restrictions at the plasma membrane Thumbnail


Authors

Suzanne Pickering

Stuart J. D. Neil



Abstract

© 2018 Foster, Pickering and Neil. Like all viruses, human immunodeficiency viruses (HIVs) and their primate lentivirus relatives must enter cells in order to replicate and, once produced, new virions need to exit to spread to new targets. These processes require the virus to cross the plasma membrane of the cell twice: once via fusion mediated by the envelope glycoprotein to deliver the viral core into the cytosol; and secondly by ESCRT-mediated scission of budding virions during release. This physical barrier thus presents a perfect location for host antiviral restrictions that target enveloped viruses in general. In this review we will examine the current understanding of innate host antiviral defences that inhibit these essential replicative steps of primate lentiviruses associated with the plasma membrane, the mechanism by which these viruses have adapted to evade such defences, and the role that this virus/host battleground plays in the transmission and pathogenesis of HIV/AIDS.

Journal Article Type Article
Acceptance Date Dec 7, 2017
Online Publication Date Jan 4, 2018
Publication Date Jan 4, 2018
Deposit Date Mar 21, 2019
Publicly Available Date Mar 21, 2019
Journal Frontiers in Immunology
Electronic ISSN 1664-3224
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 8
Article Number 1853
DOI https://doi.org/10.3389/fimmu.2017.01853
Public URL https://nottingham-repository.worktribe.com/output/1672405
Publisher URL https://www.frontiersin.org/articles/10.3389/fimmu.2017.01853/full

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