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DNA fragility in the parallel evolution of pelvic reduction in stickleback fish

Xie, Kathleen T.; Wang, Guliang; Thompson, Abbey C.; Wucherpfennig, Julia I.; Reimchen, Thomas E.; MacColl, Andrew D. C.; Schluter, Dolph; Bell, Michael A.; Vasquez, Karen M.; Kingsley, David M.

Authors

Kathleen T. Xie

Guliang Wang

Abbey C. Thompson

Julia I. Wucherpfennig

Thomas E. Reimchen

ANDREW MACCOLL ANDREW.MACCOLL@NOTTINGHAM.AC.UK
Professor of Evolutionary Ecology

Dolph Schluter

Michael A. Bell

Karen M. Vasquez

David M. Kingsley



Abstract

Evolution generates a remarkable breadth of living forms, but many traits evolve repeatedly, by mechanisms that are still poorly understood. A classic example of repeated evolution is the loss of pelvic hindfins in stickleback fish (Gasterosteus aculeatus). Repeated pelvic loss maps to recurrent deletions of a pelvic enhancer of the Pitx1 gene. Here, we identify molecular features contributing to these recurrent deletions. Pitx1 enhancer sequences form alternative DNA structures in vitro and increase double-strand breaks and deletions in vivo. Enhancer mutability depends on DNA replication direction and is caused by TG-dinucleotide repeats. Modeling shows that elevated mutation rates can influence evolution under demographic conditions relevant for sticklebacks and humans. DNA fragility may thus help explain why the same loci are often used repeatedly during parallel adaptive evolution.

Journal Article Type Article
Publication Date Jan 4, 2019
Journal Science
Print ISSN 0036-8075
Electronic ISSN 1095-9203
Publisher American Association for the Advancement of Science
Peer Reviewed Peer Reviewed
Volume 363
Issue 6422
Pages 81-84
APA6 Citation Xie, K. T., Wang, G., Thompson, A. C., Wucherpfennig, J. I., Reimchen, T. E., MacColl, A. D. C., …Kingsley, D. M. (2019). DNA fragility in the parallel evolution of pelvic reduction in stickleback fish. Science, 363(6422), 81-84. https://doi.org/10.1126/science.aan1425
DOI https://doi.org/10.1126/science.aan1425
Publisher URL http://science.sciencemag.org/content/363/6422/81

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