Christian P. Müller
The cortical neuroimmune regulator TANK affects emotional processing and enhances alcohol drinking: a translational study
Müller, Christian P.; Chu, Congying; Qin, Liya; Liu, Chunyu; Xu, Bing; Gao, He; Ruggeri, Barbara; Hieber, Saskia; Schneider, Julia; Jia, Tianye; Tay, Nicole; Akira, Shizuo; Satoh, Takashi; Banaschewski, Tobias; Bokde, Arun L.W.; Bromberg, Uli; Büchel, Christian; Quinlan, Erin Burke; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Paillère Martinot, Marie-Laure; Artiges, Eric; Lemaitre, Herve; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Paus, Tomas; Poustka, Luise; Millenet, Sabina; Fröhner, Juliane H.; Smolka, Michael N.; Walter, Henrik; Whelan, Robert; Bakalkin, Georgy; Liu, Yun; Desrivieres, Sylvane; Elliott, Paul; Eulenburg, Volker; Levy, Daniel; Crews, Fulton; Schumann, Gunter
Authors
Congying Chu
Liya Qin
Chunyu Liu
Bing Xu
He Gao
Barbara Ruggeri
Saskia Hieber
Julia Schneider
Tianye Jia
Nicole Tay
Shizuo Akira
Takashi Satoh
Tobias Banaschewski
Arun L.W. Bokde
Uli Bromberg
Christian Büchel
Erin Burke Quinlan
Herta Flor
Vincent Frouin
Hugh Garavan
Professor PENNY GOWLAND PENNY.GOWLAND@NOTTINGHAM.AC.UK
Professor of Physics
Andreas Heinz
Bernd Ittermann
Jean-Luc Martinot
Marie-Laure Paillère Martinot
Eric Artiges
Herve Lemaitre
Frauke Nees
Dimitri Papadopoulos Orfanos
Tomas Paus
Luise Poustka
Sabina Millenet
Juliane H. Fröhner
Michael N. Smolka
Henrik Walter
Robert Whelan
Georgy Bakalkin
Yun Liu
Sylvane Desrivieres
Paul Elliott
Volker Eulenburg
Daniel Levy
Fulton Crews
Gunter Schumann
Abstract
Alcohol abuse is a major public health problem worldwide. Understanding the molecular mechanisms that control regular drinking may help to reduce hazards of alcohol consumption. While immunological mechanisms have been related to alcohol drinking, most studies reported changes in immune function that are secondary to alcohol use. In this report we analyse how the gene ‘TRAF family member-associated NF-kappaB activator’ (TANK) affects alcohol drinking behaviour. Based on our recent discovery in a large GWAS dataset that suggested an association of TANK, SNP rs197273, with alcohol drinking, we report that SNP rs197273 in TANK is associated both with gene expression (p=1.16x10-19) and regional methylation (p=5.90x10-25). A tank knock out mouse model suggests a role of TANK in alcohol drinking, anxiety-related behaviour, as well as alcohol exposure induced activation of insular cortex NF-kappaB. Functional and structural neuroimaging studies among up to 1,896 adolescents reveal that TANK is involved in the control of brain activity in areas of aversive interoceptive processing, including the insular cortex, but not in areas related to reinforcement, reward processing, or impulsiveness. Our findings suggest that the cortical neuroimmune regulator TANK is associated with enhanced aversive emotional processing that better protects from the establishment of alcohol drinking behaviour.
Citation
Müller, C. P., Chu, C., Qin, L., Liu, C., Xu, B., Gao, H., …Schumann, G. (2019). The cortical neuroimmune regulator TANK affects emotional processing and enhances alcohol drinking: a translational study. Cerebral Cortex, 29(4), 1736–1751. https://doi.org/10.1093/cercor/bhy341
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 18, 2018 |
Online Publication Date | Feb 4, 2019 |
Publication Date | 2019-04 |
Deposit Date | Dec 19, 2018 |
Publicly Available Date | Dec 19, 2018 |
Journal | Cerebral Cortex |
Print ISSN | 1047-3211 |
Electronic ISSN | 1460-2199 |
Publisher | Oxford University Press |
Peer Reviewed | Peer Reviewed |
Volume | 29 |
Issue | 4 |
Pages | 1736–1751 |
DOI | https://doi.org/10.1093/cercor/bhy341 |
Keywords | Cognitive Neuroscience; Cellular and Molecular Neuroscience |
Public URL | https://nottingham-repository.worktribe.com/output/1426005 |
Publisher URL | https://academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhy341/5306317 |
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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