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Peripartum hysterectomy: an economic analysis of direct healthcare costs using routinely collected data

Achana, Felix; Fleming, Kate; Tata, Laila; Sultan, Alyshah Abdul; Petrou, Stavros


Felix Achana

Kate Fleming

Alyshah Abdul Sultan

Stavros Petrou


To estimate resource use and costs associated with peripartum hysterectomy for the English National Health Service.

Analysis of linked Clinical Practice Research Datalink and Hospital Episodes Statistics (CPRD‐HES) data.

Women undergoing peripartum hysterectomy between 1997 and 2013 and matched controls.

Inverse probability weighted generalised estimating equations were used to model the non‐linear trend in healthcare service use and costs over time, accounting for missing data, adjusting for maternal age, body mass index, delivery year, smoking and socio‐economic indicators.

Main outcome measures
Primary care, hospital outpatient and inpatient attendances and costs (UK 2015 prices).

The study sample included 1362 women (192 cases and 1170 controls) who gave birth between 1997 and 2013; 1088 (153 cases and 935 controls) of these were deliveries between 2003 and 2013 when all categories of hospital resource use were available. Based on the 2003–2013 delivery cohort, peripartum hysterectomy was associated with a mean adjusted additional total cost of £5380 (95% CI £4436–6687) and a cost ratio of 1.76 (95% CI 1.61–1.98) over 5 years of follow up compared with controls. Inpatient costs, mostly incurred during the first year following surgery, accounted for 78% excluding or 92% including delivery‐related costs.

Peripartum hysterectomy is associated with increased healthcare costs driven largely by increased post‐surgery hospitalisation rates. To reduce healthcare costs and improve outcomes for women who undergo hysterectomy, interventions that reduce avoidable repeat hospitalisations following surgery such as providing active follow up, treatment and support in the community should be considered.

Tweetable abstract
A large amount of NHS data on peripartum hysterectomy suggests active community follow up could reduce costs, #HealthEconomics.


Achana, F., Fleming, K., Tata, L., Sultan, A. A., & Petrou, S. (2018). Peripartum hysterectomy: an economic analysis of direct healthcare costs using routinely collected data. BJOG: An International Journal of Obstetrics and Gynaecology, 125(7), 874-883.

Journal Article Type Article
Acceptance Date Sep 25, 2017
Online Publication Date Nov 16, 2017
Publication Date Jun 1, 2018
Deposit Date Dec 4, 2018
Publicly Available Date Dec 5, 2018
Print ISSN 1470-0328
Electronic ISSN 1471-0528
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 125
Issue 7
Pages 874-883
Public URL
Publisher URL


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