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Structural, mechanical and swelling characteristics of 3D scaffolds from chitosan-agarose blends

Felfel, Reda M.; Gideon-Adeniyi, Mark J.; Hossain, Kazi M. Zakir; Roberts, George A.F.; Grant, David M.


Reda M. Felfel

Mark J. Gideon-Adeniyi

Kazi M. Zakir Hossain

George A.F. Roberts

Professor of Materials Science


This study aimed to explore the correlation between mechanical and structural properties of chitosan-agarose blend (Ch-Agrs) scaffolds. Porosity of Ch-Agrs scaffolds was constant at 93%, whilst pore sizes varied between 150 and 550 μm. Pore sizes of the blend scaffolds (150 - 300 μm) were significantly smaller than for either agarose or chitosan scaffolds alone (ca. 500 μm). Ch50-Agrs50 blend scaffold showed the highest compressive modulus and strength values (4.5 ± 0.4 and 0.35 ± 0.03 MPa) due to reduction in the pore size. The presence of agarose improved the stability of the blends in aqueous media. The increase in compressive properties and residual weight after the TGA test, combined with the reduction in the swelling percentage of the blend scaffolds suggested an interaction between chitosan and agarose via hydrogen bonding which was confirmed using FTIR analysis. All wet blend scaffolds exhibited instant recovery after full compression. This study shows the potential of Ch-Agrs scaffolds for repairing soft tissue.


Felfel, R. M., Gideon-Adeniyi, M. J., Hossain, K. M. Z., Roberts, G. A., & Grant, D. M. (2019). Structural, mechanical and swelling characteristics of 3D scaffolds from chitosan-agarose blends. Carbohydrate Polymers, 204, (59-67). doi:10.1016/j.carbpol.2018.10.002. ISSN 0144-8617

Journal Article Type Article
Acceptance Date Oct 1, 2018
Online Publication Date Oct 4, 2018
Publication Date Jan 15, 2019
Deposit Date Oct 4, 2018
Publicly Available Date Oct 5, 2019
Journal Carbohydrate Polymers
Print ISSN 0144-8617
Electronic ISSN 1879-1344
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 204
Pages 59-67
Keywords Chitosan; Agarose; Blend scaffolds; Compressive properties; Recovery; Pore size
Public URL
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